{"id":"W2048788153","doi":"10.1371/journal.pone.0004884","title":"Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Ontario Genomics Institute; National Institutes of Health; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Pharmaceutical Research and Manufacturers of America Foundation; Wellcome Trust; VINNOVA; Stiftelsen för Strategisk Forskning","keywords":"GTPase; Cell biology; GTPase-activating protein; Effector; Biology; Small GTPase; MAPK/ERK pathway; Signal transduction; Guanine nucleotide exchange factor; G protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827968,0.0001609506,0.0002439305,0.00006238518,0.00006285453,0.00001308323,0.0001246709,0.0001594418,0.00007457217],"category_scores_gemma":[0.0001324904,0.0001634422,0.0001056645,0.0001590431,0.00004402246,0.000004823942,0.00003149093,0.0000917885,0.00001529364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001857835,"about_ca_system_score_gemma":0.00006009019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005690083,"about_ca_topic_score_gemma":0.000001181823,"domain_scores_codex":[0.9988773,0.0000725309,0.0002438196,0.0003190222,0.0002662383,0.0002210373],"domain_scores_gemma":[0.9992606,0.000009692053,0.0001396936,0.000297103,0.0002042798,0.00008862559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001455501,0.0003826425,0.0001918732,0.00006043719,0.0001341898,0.000001687538,0.00004856475,0.00001449988,0.9980083,0.0001119,0.000118569,0.000781808],"study_design_scores_gemma":[0.0005807728,0.0005641766,0.0007712836,0.0002029711,0.0000549536,0.000001363302,0.000007006525,0.000167189,0.9968346,0.0004063285,0.0002184917,0.0001908885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968985,0.001041964,0.0008072969,0.0002190802,0.00001008607,0.0004753986,0.00002052266,0.00002627031,0.000500877],"genre_scores_gemma":[0.994401,0.0000137553,0.004508452,0.0002838054,0.0001924207,0.00002548576,0.00004348874,0.00001918614,0.0005124336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003701154,"threshold_uncertainty_score":0.6664979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669418580463134,"score_gpt":0.225752380713863,"score_spread":0.2090581949092317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}