{"id":"W2048809853","doi":"10.1007/s13346-013-0161-z","title":"Lipid nanoparticle delivery systems for siRNA-based therapeutics","year":2013,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of British Columbia","funders":"Canadian Institutes of Health Research; Alnylam Pharmaceuticals","keywords":"Liposome; In vivo; Oligonucleotide; Chemistry; Small interfering RNA; Cationic liposome; Endosome; Delivery system; Small molecule; Drug delivery; Pharmacology; Transfection; Biochemistry; Cell; Medicine; Biology; Biotechnology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000316946,0.0003693244,0.0002463742,0.0002492644,0.00030024,0.0004097364,0.0002429777,0.0004734536,0.001160807],"category_scores_gemma":[0.0002389068,0.0002174057,0.0002079077,0.0001307474,0.0002201918,0.0004745545,0.0003156815,0.0004725098,0.0009166242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005926065,"about_ca_system_score_gemma":0.0003535383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006006732,"about_ca_topic_score_gemma":0.0008159815,"domain_scores_codex":[0.999879,0.00002639378,0.000009397558,0.00002735932,0.00003643505,0.00002136402],"domain_scores_gemma":[0.9999353,0.00001868508,0.00001512255,0.000003962964,0.00001713558,0.000009738681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004773906,0.00001084384,0.00001708072,0.000103095,0.000005106775,0.00004887339,0.00002692587,0.0001870117,0.9948083,0.0007108223,0.0001377671,0.003896421],"study_design_scores_gemma":[0.00001343189,0.0001300716,0.00009337797,0.000009331144,0.00001597247,0.000104308,0.00001029457,0.001386697,0.9906025,0.0001390003,0.007487895,0.000007141954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7304658,0.02109562,0.2330731,0.001354654,0.0004274529,0.0005778203,0.0006177522,0.001131525,0.01125628],"genre_scores_gemma":[0.9019288,0.009077871,0.06846815,0.0004796206,0.00006706445,0.0004652081,0.0006367967,0.0001732981,0.01870327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160807,"threshold_uncertainty_score":0.004299641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05862364560679965,"score_gpt":0.3250428681221331,"score_spread":0.2664192225153335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}