{"id":"W2048837651","doi":"10.1021/bi061536l","title":"Substrate Binding and Catalytic Mechanism of Human Choline Acetyltransferase<sup>,</sup>","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Choline acetyltransferase; Choline; Chemistry; Enzyme; Acetylcholine; Serine; Binding site; Transferase; Ternary complex; Stereochemistry; Cholinergic; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672732,0.0003678746,0.000326391,0.00009496415,0.0002778924,0.0006242873,0.0008054049,0.0006631877,0.001249769],"category_scores_gemma":[0.0003590009,0.000288607,0.000231122,0.0001486585,0.0003448997,0.0004562176,0.0001873844,0.0004737823,0.0008013377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009289595,"about_ca_system_score_gemma":0.0004079016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003706811,"about_ca_topic_score_gemma":0.001935877,"domain_scores_codex":[0.9998455,0.00002489624,0.000009540622,0.00004838114,0.00004699244,0.00002464649],"domain_scores_gemma":[0.9999033,0.00002251154,0.00001795379,0.00001120943,0.00002336744,0.00002157268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001017983,0.0001619051,0.004850505,0.0004215699,0.00007909246,0.0008206229,0.0002631154,0.004569032,0.9657363,0.004859562,0.0009033918,0.01631691],"study_design_scores_gemma":[0.00006527985,0.0002194424,0.008577405,0.00002517264,0.00003638166,0.001468919,0.000130831,0.02971898,0.950168,0.0009593958,0.008586884,0.00004339677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812683,0.00572146,0.008749356,0.0004366419,0.0000466768,0.00002572436,0.0002256003,0.0001847805,0.003341341],"genre_scores_gemma":[0.9888949,0.001270817,0.006120193,0.00008630913,0.000009016349,0.00001217333,0.0007196369,0.0000185525,0.002868354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003706811,"threshold_uncertainty_score":0.007370472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006431923376416851,"score_gpt":0.2237018258460513,"score_spread":0.2172699024696344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}