{"id":"W2048845953","doi":"10.1124/jpet.103.060434","title":"Interaction of the Novel Adenosine Uptake Inhibitor 3-[1-(6,7-Diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1 H,3 H)-quinazolinedione Hydrochloride (KF24345) with the es and ei Subtypes of Equilibrative Nucleoside Transporters","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Nucleoside transporter; Nucleoside; Adenosine; Transporter; Chemistry; Biochemistry; Pharmacology; Non-competitive inhibition; Stereochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002131764,0.0002670402,0.0004668015,0.0001219356,0.000176961,0.0003416487,0.0005208468,0.0004083225,0.002000548],"category_scores_gemma":[0.000257202,0.0001793008,0.0002442787,0.0001723377,0.0001743782,0.0002498192,0.0001549711,0.00055964,0.000456198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003312136,"about_ca_system_score_gemma":0.0003800392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101334,"about_ca_topic_score_gemma":0.001838867,"domain_scores_codex":[0.9998276,0.0000311494,0.00001664324,0.00003251932,0.0000304949,0.00006153064],"domain_scores_gemma":[0.9999218,0.00002658777,0.00001554897,0.000009554918,0.000006193181,0.00002036053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001661476,0.0002298862,0.0002717868,0.0001270492,0.00004760957,0.0002063508,0.0000561977,0.0003205096,0.991357,0.0004388055,0.000367831,0.004915477],"study_design_scores_gemma":[0.0005232931,0.003404401,0.005505737,0.00001351539,0.00007129622,0.0005978156,0.00006006738,0.003158717,0.9808581,0.00007591737,0.005709222,0.00002181409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941199,0.002139477,0.001027885,0.0001592874,0.00007395805,0.00005363681,0.0002689594,0.00008755739,0.002069413],"genre_scores_gemma":[0.9962915,0.0007968222,0.0009329183,0.00005790537,0.00003296345,0.00003849861,0.000454831,0.000009042154,0.00138546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002000548,"threshold_uncertainty_score":0.006692469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556982123773024,"score_gpt":0.2869335581328653,"score_spread":0.271363736895135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}