{"id":"W2048898883","doi":"10.1074/jbc.m111.229419","title":"Critical Role of the β-Subunit CDC50A in the Stable Expression, Assembly, Subcellular Localization, and Lipid Transport Activity of the P4-ATPase ATP8A2","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Canadian Institutes of Health Research","keywords":"Flippase; Phosphatidylserine; Endoplasmic reticulum; Phosphatidylethanolamine; Cell biology; Biochemistry; Transmembrane domain; Transport protein; Biology; Protein subunit; Membrane protein; Transmembrane protein; ATPase; Subcellular localization; Membrane; Cytoplasm; Chemistry; Phosphatidylcholine; Enzyme; Phospholipid; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746888,0.0003888829,0.0001956917,0.0002483698,0.0003187228,0.0005378187,0.0003065194,0.0003669625,0.001278443],"category_scores_gemma":[0.0002622073,0.0002258419,0.0002176301,0.0001255397,0.0003047702,0.0002222474,0.0003587816,0.0004798355,0.0007555924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005008741,"about_ca_system_score_gemma":0.0003769259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001191417,"about_ca_topic_score_gemma":0.001213284,"domain_scores_codex":[0.9998597,0.00002159683,0.00002073209,0.00003709857,0.00003583865,0.00002503731],"domain_scores_gemma":[0.9997837,0.00004342089,0.00003971584,0.00002908903,0.00002461962,0.000079399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006752359,0.00001588437,0.0001299719,0.00001353582,0.000001930745,0.0000610104,0.000008259144,0.00003046626,0.9988883,0.0001268463,0.0000259356,0.0006302953],"study_design_scores_gemma":[0.00002268066,0.00005098626,0.00758929,0.00001187626,0.00001072603,0.000409707,0.00003050257,0.001867826,0.9871869,0.000105622,0.002708351,0.000005554983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937364,0.002515502,0.001676818,0.0001287318,0.00005525945,0.0000191192,0.0003109647,0.00007262859,0.001484568],"genre_scores_gemma":[0.9960915,0.0005163487,0.001189362,0.00004394594,0.000008142597,0.00002815538,0.0004851116,0.00003997322,0.001597326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001278443,"threshold_uncertainty_score":0.004276752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758843631224285,"score_gpt":0.2381296121211628,"score_spread":0.2205411758089199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}