{"id":"W2048935601","doi":"10.1093/toxsci/kfh015","title":"Cadmium-Induced Mitochondrial Membrane-Potential Dissipation Does Not Necessarily Require Cytosolic Oxidative Stress: Studies Using Rhodamine-123 Fluorescence Unquenching","year":2003,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dichlorofluorescein; Rhodamine 123; Chemistry; Oxidative stress; Mannitol; Reactive oxygen species; Biophysics; Flow cytometry; Membrane potential; Cytosol; Fluorescence microscope; Fluorescence; Biochemistry; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001230628,0.0003757948,0.0004888012,0.00007503431,0.001349753,0.0001998356,0.0006670567,0.0002350985,0.001011425],"category_scores_gemma":[0.002049053,0.0002260762,0.000139309,0.0008998462,0.001650716,0.001410972,0.0003127218,0.00033683,0.0000858114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000295452,"about_ca_system_score_gemma":0.00008906193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004047268,"about_ca_topic_score_gemma":0.0003999285,"domain_scores_codex":[0.9956741,0.0007085917,0.0006129388,0.001046927,0.001109602,0.0008477864],"domain_scores_gemma":[0.9987032,0.0003726048,0.0003114892,0.0002784329,0.00003711749,0.0002971172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003498491,0.0002069446,0.004687678,0.000009291521,0.00001902757,0.00004212735,0.0005917621,0.002095407,0.9900192,0.0006561969,0.00001772051,0.001619654],"study_design_scores_gemma":[0.0004734334,0.000749536,0.01311446,0.00004952581,0.00004954347,0.00002157982,0.001198524,0.00291748,0.9771867,0.003446681,0.0001914212,0.0006011079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945692,0.00004538702,0.0008102767,0.0003688181,0.001011468,0.0004692615,0.00001715924,0.00009559199,0.002612795],"genre_scores_gemma":[0.9918396,0.00004063729,0.007393935,0.0003042832,0.0001965838,0.00003067515,0.000002411749,0.00001017039,0.0001817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0128325,"threshold_uncertainty_score":0.9999503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07967719021094923,"score_gpt":0.3378865600175844,"score_spread":0.2582093698066352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}