{"id":"W2048935601","doi":"10.1093/toxsci/kfh015","title":"Cadmium-Induced Mitochondrial Membrane-Potential Dissipation Does Not Necessarily Require Cytosolic Oxidative Stress: Studies Using Rhodamine-123 Fluorescence Unquenching","year":2003,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Heavy Metal Exposure and Toxicity","field":"Environmental Science","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dichlorofluorescein; Rhodamine 123; Chemistry; Oxidative stress; Mannitol; Reactive oxygen species; Biophysics; Flow cytometry; Membrane potential; Cytosol; Fluorescence microscope; Fluorescence; Biochemistry; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003014662,0.000341305,0.000372629,0.000123579,0.0001870197,0.000358299,0.0003027104,0.0004478752,0.0007467883],"category_scores_gemma":[0.0003152021,0.0001867259,0.0002599982,0.000155822,0.0003058084,0.0003697914,0.0002685302,0.0006912065,0.0003509091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003782118,"about_ca_system_score_gemma":0.0001833676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192984,"about_ca_topic_score_gemma":0.001641982,"domain_scores_codex":[0.9998253,0.00003918636,0.00001510052,0.0000409248,0.00004573161,0.00003375841],"domain_scores_gemma":[0.9997757,0.00005971179,0.00005500609,0.00003005188,0.00005622209,0.00002321775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005359095,0.000007872166,0.0001244489,0.00002998769,0.000003932356,0.00003820648,0.00002533099,0.00001445756,0.9991678,0.00003764091,0.00001109719,0.000485633],"study_design_scores_gemma":[0.000006372632,0.0001016286,0.002143807,0.00000267953,0.00001055128,0.0001100056,0.00002335211,0.0005310532,0.9962812,0.00001619169,0.000768363,0.000004661126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810213,0.001912302,0.0151545,0.0001730064,0.00003757754,0.00004522586,0.0002563476,0.00009127838,0.001308597],"genre_scores_gemma":[0.9853124,0.001307644,0.009871171,0.00007523906,0.00001555029,0.00006083464,0.0005747179,0.00005901776,0.002723349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192984,"threshold_uncertainty_score":0.002744079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07967719021094923,"score_gpt":0.3378865600175844,"score_spread":0.2582093698066352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}