{"id":"W2048966304","doi":"10.1371/journal.pmed.0040182","title":"Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model","year":2007,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; McGill University; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Neuroprotection; Lithium (medication); Neuroscience; Dendritic spine; Lithium carbonate; Hippocampal formation; Pathogenesis; Hippocampus; Ataxia; Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Medicine; Psychology; Internal medicine; Disease; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117081,0.001034192,0.0009003514,0.0007023226,0.0003031615,0.000352139,0.0005503204,0.0008418169,0.001738279],"category_scores_gemma":[0.000106245,0.0001698716,0.0003685046,0.0002682014,0.0003234889,0.0004562294,0.0001680952,0.001028591,0.0005220384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005582075,"about_ca_system_score_gemma":0.0003926572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001362056,"about_ca_topic_score_gemma":0.003055734,"domain_scores_codex":[0.999898,0.00001131911,0.00001639645,0.00002228169,0.00002810889,0.0000238346],"domain_scores_gemma":[0.9998453,0.000006258299,0.00005632191,0.00001170371,0.00001908512,0.0000612482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001913266,0.001086807,0.0009173424,0.0002042428,0.00006066939,0.0001842667,0.00004870257,0.0001706243,0.9862089,0.0001110933,0.0008684101,0.00822562],"study_design_scores_gemma":[0.001293125,0.01770774,0.01842491,0.0001197949,0.0004809152,0.001293153,0.0001405514,0.00310476,0.9471285,0.0003314882,0.009908153,0.00006692795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932795,0.002316894,0.0007526418,0.0003875539,0.00007971502,0.00005845919,0.0009023721,0.0006090588,0.001613914],"genre_scores_gemma":[0.9855149,0.002285396,0.002239114,0.000272331,0.00004404616,0.0002310701,0.002262254,0.00006725935,0.007083708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001738279,"threshold_uncertainty_score":0.005815148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04664501103469994,"score_gpt":0.2741238406052254,"score_spread":0.2274788295705255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}