{"id":"W2048996428","doi":"10.1016/j.pbiomolbio.2007.07.011","title":"Contributions of HERG <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" altimg=\"si92.gif\" overflow=\"scroll\"><mml:msup><mml:mrow><mml:mi mathvariant=\"normal\">K</mml:mi></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:math> current to repolarization of the human ventricular action potential","year":2007,"lang":"lv","type":"review","venue":"Progress in Biophysics and Molecular Biology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"University of California, San Diego; Canadian Institutes of Health Research; National Research Foundation; Heart and Stroke Foundation of Canada","keywords":"hERG; Repolarization; Ventricular action potential; Cardiac action potential; Cardiac electrophysiology; Chemistry; Atrial action potential; Electrophysiology; Computer science; Potassium channel; Biophysics; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001038681,0.0006284888,0.0005576165,0.0003630065,0.0007220671,0.0001840781,0.000752799,0.001946023,0.005574193],"category_scores_gemma":[0.0005912953,0.0009033371,0.001623709,0.0009775297,0.001377068,0.0002625099,0.001055283,0.001359239,0.0001310627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000205935,"about_ca_system_score_gemma":0.0009064386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003605834,"about_ca_topic_score_gemma":0.00004698822,"domain_scores_codex":[0.99454,0.0005516007,0.00150854,0.001186469,0.0008925068,0.00132093],"domain_scores_gemma":[0.9958942,0.000335449,0.001896184,0.001249591,0.0002331103,0.0003914933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008319817,0.0004542777,0.00002054091,0.002899739,0.001877879,0.001307372,0.0003141207,0.0002613842,0.01856557,0.9496696,0.002314475,0.02148304],"study_design_scores_gemma":[0.001997277,0.002558905,0.0001992411,0.003188229,0.003321253,0.002390521,0.0002108001,0.01718343,0.9608741,0.0002585448,0.006745327,0.0010724],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.910717,0.06537867,0.002621384,0.0003887608,0.002866686,0.000198982,0.0004642254,0.00008366824,0.0172806],"genre_scores_gemma":[0.9696227,0.02544357,0.0004416415,0.0003295048,0.001370721,0.0006714373,0.001868236,0.0002294938,0.00002264109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9494111,"threshold_uncertainty_score":0.9993497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154989935496306,"score_gpt":0.286340070302956,"score_spread":0.2708410767533254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}