{"id":"W2049009935","doi":"10.1089/jir.2008.0144","title":"A Biosensor-Based Characterization of the Affinity Maturation of the Immune Response Against Interferon-β and Correlations with Neutralizing Antibodies in Treated Multiple Sclerosis Patients","year":2008,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Multiple Sclerosis Society; University of Regina","keywords":"Antibody; Surface plasmon resonance; Titer; Dissociation rate; Immune system; Chemistry; Immunology; Affinity maturation; Antibody titer; Multiple sclerosis; Dissociation (chemistry); Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004031874,0.0003419544,0.0004894228,0.0004211142,0.0001235339,0.0003216852,0.0002400537,0.0006672274,0.0004811624],"category_scores_gemma":[0.001116887,0.0001661257,0.0002046604,0.000304359,0.0001002318,0.0001505146,0.0001124285,0.0005114738,0.0002383698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074902,"about_ca_system_score_gemma":0.0001024453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009237349,"about_ca_topic_score_gemma":0.0006274203,"domain_scores_codex":[0.9996537,0.00008748543,0.00003138633,0.00006476432,0.0001255046,0.00003718989],"domain_scores_gemma":[0.999619,0.00008195396,0.0001241178,0.00002993442,0.0001071322,0.00003779499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002609759,0.0004270441,0.1166166,0.0001540484,0.0001421786,0.0002956674,0.0002949584,0.000928893,0.8452976,0.00007219973,0.0002125535,0.03294858],"study_design_scores_gemma":[0.0001117121,0.006928987,0.691377,0.00002997634,0.0002212074,0.006190958,0.0002827858,0.009526031,0.2832746,0.00009933473,0.001904012,0.0000534514],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966154,0.001100597,0.001391147,0.00002707612,0.00001007879,0.00001602802,0.0001757039,0.00004424284,0.0006197949],"genre_scores_gemma":[0.9973044,0.0002627895,0.001701395,0.00003799739,0.000007066374,0.00001813512,0.0003093115,0.000003969263,0.000354899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009237349,"threshold_uncertainty_score":0.002132237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08047013816186412,"score_gpt":0.304942610250948,"score_spread":0.2244724720890839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}