{"id":"W2049009935","doi":"10.1089/jir.2008.0144","title":"A Biosensor-Based Characterization of the Affinity Maturation of the Immune Response Against Interferon-β and Correlations with Neutralizing Antibodies in Treated Multiple Sclerosis Patients","year":2008,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Multiple Sclerosis Society; University of Regina","keywords":"Antibody; Surface plasmon resonance; Titer; Dissociation rate; Immune system; Chemistry; Immunology; Affinity maturation; Antibody titer; Multiple sclerosis; Dissociation (chemistry); Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001063474,0.0001455845,0.0004048011,0.0005353265,0.0001997029,0.00001800318,0.0002456004,0.00008469786,0.00001175091],"category_scores_gemma":[0.0007558783,0.00007441073,0.0001409286,0.0008100533,0.0006383943,0.0001609451,0.0001430149,0.0007690666,8.513737e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390807,"about_ca_system_score_gemma":0.0002828239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819666,"about_ca_topic_score_gemma":0.00006231602,"domain_scores_codex":[0.9971172,0.0008459133,0.0007646536,0.0001455056,0.0008698296,0.0002569095],"domain_scores_gemma":[0.9972904,0.0006063136,0.0004447144,0.000260199,0.001319014,0.00007937269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02071267,0.0003425751,0.385181,0.00007488886,0.00004498047,0.000007544198,0.0005727996,0.00004345707,0.5927004,0.000005461136,0.00001964218,0.000294602],"study_design_scores_gemma":[0.00185073,0.001623154,0.6927252,0.001442305,0.00001214011,0.00003179564,0.0001453308,0.0006821758,0.3014073,0.000001314905,0.00003301109,0.00004557529],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970914,0.0001010729,0.00001466842,0.002136474,0.00006125,0.0004911877,0.00004831213,0.00000336293,0.00005227842],"genre_scores_gemma":[0.9993146,0.0003813116,0.00006576921,0.00003105177,0.00003372925,0.000005085159,0.0000146966,0.00001687641,0.0001368977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3075441,"threshold_uncertainty_score":0.3341255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08047013816186412,"score_gpt":0.304942610250948,"score_spread":0.2244724720890839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}