{"id":"W2049020763","doi":"10.1111/febs.12564","title":"Validity of the Michaelis–Menten equation – steady‐state or reactant stationary assumption: that is the question","year":2013,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Lethbridge; James S. McDonnell Foundation","keywords":"Michaelis–Menten kinetics; Steady state (chemistry); Thermodynamics; Stationary state; Chemistry; Substrate (aquarium); Rate equation; Kinetic energy; Transient (computer programming); Mathematics; Applied mathematics; Kinetics; Physics; Physical chemistry; Computer science; Classical mechanics; Enzyme; Enzyme assay","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003096454,0.0009542565,0.002822595,0.001509068,0.0005108141,0.002211744,0.002804115,0.002990624,0.002267943],"category_scores_gemma":[0.003519558,0.0005363114,0.0009918942,0.001748844,0.002785062,0.003695354,0.000892102,0.002904236,0.004344716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001781357,"about_ca_system_score_gemma":0.00198633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001465829,"about_ca_topic_score_gemma":0.0007143046,"domain_scores_codex":[0.9986268,0.0002988488,0.0001514261,0.000332499,0.000495775,0.00009464342],"domain_scores_gemma":[0.9979532,0.001323603,0.0001896996,0.0001099932,0.0003685273,0.00005491619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000105109,0.00008272662,0.0004570003,0.02714715,0.0001954548,0.0006883265,0.0002188322,0.002156093,0.006156204,0.1116849,0.02909208,0.8220161],"study_design_scores_gemma":[0.00001406852,0.0001393368,0.0006071299,0.002428753,0.00009606603,0.00155085,0.0001262539,0.0006505986,0.00447989,0.02843293,0.9613928,0.00008135147],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004411799,0.9862428,0.005237383,0.001952616,0.0008697732,0.00001584096,0.00004787549,0.00003855642,0.005154017],"genre_scores_gemma":[0.005683035,0.9875514,0.003112681,0.0008778974,0.0007897785,0.00004403593,0.0001022547,0.00001771568,0.001821159],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003096454,"threshold_uncertainty_score":0.01637578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07012045970109651,"score_gpt":0.3400312675379905,"score_spread":0.2699108078368939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}