{"id":"W2049020763","doi":"10.1111/febs.12564","title":"Validity of the Michaelis–Menten equation – steady‐state or reactant stationary assumption: that is the question","year":2013,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Lethbridge; James S. McDonnell Foundation","keywords":"Michaelis–Menten kinetics; Steady state (chemistry); Thermodynamics; Stationary state; Chemistry; Substrate (aquarium); Rate equation; Kinetic energy; Transient (computer programming); Mathematics; Applied mathematics; Kinetics; Physics; Physical chemistry; Computer science; Classical mechanics; Enzyme; Enzyme assay","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006305088,0.0002431711,0.0003663223,0.00004084317,0.0001978404,0.00006923455,0.0004391783,0.0002465525,0.0000724504],"category_scores_gemma":[0.0001282772,0.000111252,0.000359646,0.00009182686,0.00008255615,0.00001302481,0.0001315386,0.0004273135,0.000009264261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006333363,"about_ca_system_score_gemma":0.0003796857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001290381,"about_ca_topic_score_gemma":0.00001278404,"domain_scores_codex":[0.9982319,0.0005461031,0.0004917358,0.0002058363,0.0003486992,0.0001757395],"domain_scores_gemma":[0.9982068,0.00005064462,0.001055565,0.0004196637,0.0002139315,0.00005337187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006897846,0.00005528472,0.0001184509,0.001681742,0.0005072374,0.000007122009,0.0001718738,0.00003333975,0.0008536042,0.000180695,0.01228616,0.9840355],"study_design_scores_gemma":[0.0001833126,0.0001446879,0.0001841988,0.001490561,0.0004064433,0.0005776834,0.00003443085,0.00005009129,0.0005167893,0.001329183,0.9948697,0.00021292],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000881253,0.9908082,0.005728562,0.0004081408,0.0008930355,0.0008961466,0.0002132059,0.000005450905,0.0001660367],"genre_scores_gemma":[0.0007389081,0.9964293,0.0004686115,0.0001670422,0.0005041379,0.00003647239,0.0002148965,0.000027822,0.001412856],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9838226,"threshold_uncertainty_score":0.4536726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07012045970109651,"score_gpt":0.3400312675379905,"score_spread":0.2699108078368939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}