{"id":"W2049086053","doi":"10.1093/annonc/mdv050.12","title":"Afatinib (A) Vs Erlotinib (E) as Second-Line Treatment of Patients (PTS) with Advanced Squamous Cell Carcinoma (SCC) of the Lung Following First-Line Platinum-Based Chemotherapy: Lux-Lung 8 (LL8), a Phase Iii Global Trial","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Medicine; Afatinib; Internal medicine; Clinical endpoint; Lung cancer; Erlotinib; Oncology; Progression-free survival; Chemotherapy regimen; Surrogate endpoint; Chemotherapy; Surgery; Gastroenterology; Randomized controlled trial; Cancer; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036227,0.001109448,0.001909957,0.0003403054,0.0002747018,0.001069377,0.0008870884,0.001286775,0.003765897],"category_scores_gemma":[0.0008961389,0.0003661406,0.001765461,0.0003537609,0.0006676227,0.001359486,0.0003438373,0.003105343,0.0008723564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007052087,"about_ca_system_score_gemma":0.0007994514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000842509,"about_ca_topic_score_gemma":0.003548931,"domain_scores_codex":[0.9997358,0.0001099617,0.00001816543,0.00005236719,0.00001815878,0.00006571261],"domain_scores_gemma":[0.9995229,0.00008758133,0.00009914815,0.00003028133,0.00002599307,0.0002341577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8468481,0.009854921,0.004207686,0.001173365,0.002420571,0.0001469619,0.0001777951,0.001931633,0.008755352,0.0003454517,0.004655422,0.1194828],"study_design_scores_gemma":[0.8199687,0.1635132,0.008134579,0.0001016012,0.001438144,0.0003302117,0.0001460307,0.001490406,0.001355278,0.000525972,0.002947864,0.00004795417],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894128,0.005354647,0.0002419323,0.001008139,0.0002727308,0.0005234399,0.0008619024,0.0001330035,0.002191303],"genre_scores_gemma":[0.9901919,0.003359991,0.000631977,0.001002091,0.0001557666,0.0004622406,0.001162476,0.00002656483,0.003007005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003765897,"threshold_uncertainty_score":0.01259822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04037316368819774,"score_gpt":0.3937972074679882,"score_spread":0.3534240437797904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}