{"id":"W2049116607","doi":"10.1089/hum.2010.225","title":"Local Long-Term Expression of Lentivirally Delivered IL-10 in the Lung Attenuates Obliteration of Intrapulmonary Allograft Airways","year":2011,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network","funders":"International Society for Heart and Lung Transplantation; International Society for Heart and Lung Transplants","keywords":"Lung transplantation; Lung; Transplantation; Transfection; Cystic fibrosis; Genetic enhancement; Transgene; Medicine; Transduction (biophysics); Luciferase; Green fluorescent protein; Immune system; Cytokine; Viral vector; Pathology; Immunology; Biology; Cancer research; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003453247,0.0001277763,0.0002569877,0.0001210962,0.00004416247,0.000005618464,0.0001417326,0.00007184623,0.0003482153],"category_scores_gemma":[0.000003060482,0.0000831046,0.0001032246,0.0001138531,0.000111846,0.00009282348,0.000009225673,0.00009865136,0.000001660671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001146415,"about_ca_system_score_gemma":0.00002088174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005385683,"about_ca_topic_score_gemma":0.00002473376,"domain_scores_codex":[0.9989294,0.0001914131,0.0003754228,0.0001614075,0.000209725,0.0001326424],"domain_scores_gemma":[0.9994497,0.00006202737,0.0001295015,0.0002563022,0.00007612964,0.0000262936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001118061,0.0004291995,0.2493467,0.0001316515,0.00004712099,0.00004735886,0.01095274,0.000005052828,0.7230514,0.0001771763,0.00005483091,0.01463864],"study_design_scores_gemma":[0.001434712,0.0004184116,0.6479779,0.0001329589,0.00002965527,0.00001334707,0.0001486453,0.00002779916,0.3495001,0.0002391162,0.00001059562,0.00006676038],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888049,0.001218473,0.009217614,0.00004324135,0.00003745411,0.000361762,0.00001112323,0.00001578696,0.0002895908],"genre_scores_gemma":[0.9959299,0.0005498156,0.003143079,0.0001346694,0.00003996282,0.00001785162,0.00009915193,0.00001468902,0.00007090861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3986312,"threshold_uncertainty_score":0.3812713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06107622551578341,"score_gpt":0.3215188174577979,"score_spread":0.2604425919420145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}