{"id":"W2049116850","doi":"10.1016/j.bmcl.2007.05.024","title":"Primary amides as selective inhibitors of cathepsin K","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Carboxamide; Primary (astronomy); Stereochemistry; Chemical synthesis; Enzyme inhibitor; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003672334,0.0005793968,0.0004411219,0.0003103684,0.0001722784,0.0003208518,0.0004317584,0.000386715,0.002949278],"category_scores_gemma":[0.0002132252,0.0003278592,0.0002798057,0.0001874094,0.0002491016,0.0003613189,0.0002879872,0.00082682,0.0007562808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003192115,"about_ca_system_score_gemma":0.0002367718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004481094,"about_ca_topic_score_gemma":0.0010797,"domain_scores_codex":[0.9998645,0.0000263208,0.00001029641,0.00001715052,0.00002817642,0.00005362596],"domain_scores_gemma":[0.9999214,0.00001809894,0.0000146468,0.000007912936,0.00001075105,0.0000270942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002436417,0.000303859,0.0002481269,0.0004153134,0.00006101705,0.0007140466,0.0001367885,0.001589677,0.9626798,0.00177765,0.001957735,0.02767965],"study_design_scores_gemma":[0.001262078,0.006175512,0.001779279,0.00004142288,0.00009965208,0.001476737,0.0000527635,0.001826242,0.9631845,0.0005332173,0.02352269,0.00004586307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398088,0.02425059,0.008094324,0.0007340708,0.0006627775,0.0003374712,0.0009913979,0.0005222088,0.02459837],"genre_scores_gemma":[0.9752637,0.01290035,0.002245414,0.0002625814,0.00009750923,0.00008981446,0.0005580402,0.00003903497,0.008543359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002949278,"threshold_uncertainty_score":0.009866297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004101317911104719,"score_gpt":0.2183724571387366,"score_spread":0.2142711392276319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}