{"id":"W2049116850","doi":"10.1016/j.bmcl.2007.05.024","title":"Primary amides as selective inhibitors of cathepsin K","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Carboxamide; Primary (astronomy); Stereochemistry; Chemical synthesis; Enzyme inhibitor; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002930154,0.0002218347,0.0002446973,0.00003391596,0.00005279834,0.000007008085,0.0002278331,0.000155341,0.00006977063],"category_scores_gemma":[0.0002115309,0.0002056853,0.0001199958,0.0001859889,0.000296464,0.000004762423,0.00008552444,0.0001321873,0.000009620755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003763776,"about_ca_system_score_gemma":0.0001732942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006191182,"about_ca_topic_score_gemma":0.000003132311,"domain_scores_codex":[0.9986103,0.00002168559,0.0003369716,0.0003822904,0.000305723,0.0003429858],"domain_scores_gemma":[0.9991906,0.0000259523,0.0001603622,0.0003386447,0.00008442974,0.0002000135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001942021,0.00008529613,0.003585367,0.00009342853,0.00005933625,0.00002233105,0.00006993868,4.481934e-7,0.9885107,0.000004008821,0.006487214,0.0008877703],"study_design_scores_gemma":[0.0006074473,0.00005160648,0.01342654,0.00003408011,0.00007198841,0.0000610514,0.0001948205,1.952696e-7,0.9795215,0.0000144423,0.005805338,0.0002110588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943296,0.00239709,0.0002658204,0.0004548347,0.0001518137,0.0001033128,0.00001616508,0.00002258759,0.002258722],"genre_scores_gemma":[0.9968086,0.00008128479,0.0001666186,0.001689443,0.0009064917,0.000003925402,0.0001249208,0.00002990727,0.0001887645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009841169,"threshold_uncertainty_score":0.8387601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004101317911104719,"score_gpt":0.2183724571387366,"score_spread":0.2142711392276319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}