{"id":"W2049125266","doi":"10.1074/jbc.m306177200","title":"Cytosolic Prion Protein Is Not Toxic and Protects against Bax-mediated Cell Death in Human Primary Neurons","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Cytosol; Endoplasmic-reticulum-associated protein degradation; Neurodegeneration; Biology; Cell biology; Programmed cell death; Endoplasmic reticulum; Lactacystin; Proteasome; Complementary DNA; Molecular biology; Apoptosis; Proteasome inhibitor; Biochemistry; Unfolded protein response; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003266563,0.0002013527,0.0002648467,0.00003177906,0.00007091545,0.00002868502,0.0001952406,0.000311062,0.00004715678],"category_scores_gemma":[0.0003035725,0.0001579513,0.0001293305,0.00008731668,0.00007399027,0.000007277621,0.00009162827,0.0003328235,0.000001242213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003355161,"about_ca_system_score_gemma":0.0001147822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001365476,"about_ca_topic_score_gemma":2.509162e-7,"domain_scores_codex":[0.9987409,0.0001081788,0.0004298514,0.0002977106,0.0001444783,0.0002788837],"domain_scores_gemma":[0.9992418,0.00001790476,0.0002923358,0.0001808372,0.00006607958,0.0002010367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001314785,0.0001428279,0.003436375,0.00008306258,0.00001287486,0.00004373387,0.000008262253,0.000004646864,0.9952211,0.00000375099,0.0000474199,0.0008644683],"study_design_scores_gemma":[0.001085513,0.0003519919,0.005003831,0.00006522066,0.000006187735,0.00005579864,0.00001696065,0.000004721292,0.9888769,0.00008709318,0.004243203,0.0002025121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957264,0.003167286,0.00004007915,0.0001004796,0.0000185467,0.0002506824,0.00001298546,0.000006371713,0.0006771776],"genre_scores_gemma":[0.9975022,0.001271699,0.0004721515,0.0004855164,0.0001216472,0.00001744718,0.00002065728,0.0000139508,0.0000947326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006344131,"threshold_uncertainty_score":0.6441066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735376590603563,"score_gpt":0.2416950831863182,"score_spread":0.2243413172802825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}