{"id":"W2049128436","doi":"10.1089/adt.2007.120","title":"Functional Properties of <i>α</i> 7 Nicotinic Acetylcholine Receptors Co-expressed with RIC-3 in a Stable Recombinant CHO-K1 Cell Line","year":2008,"lang":"en","type":"article","venue":"Assay and Drug Development Technologies","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chinese hamster ovary cell; Nicotinic agonist; Acetylcholine receptor; Allosteric modulator; Allosteric regulation; Chemistry; Patch clamp; Receptor; Cell biology; Agonist; Biophysics; Heterologous expression; Biology; Biochemistry; Molecular biology; Recombinant DNA; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004218951,0.0004531211,0.0005746183,0.0002413269,0.000209552,0.0006653772,0.0006635949,0.0004160643,0.001139423],"category_scores_gemma":[0.0003078067,0.0001753343,0.0006203892,0.0004691068,0.0002583434,0.0003476803,0.0003289381,0.0006783052,0.001799528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006562284,"about_ca_system_score_gemma":0.0001953697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008814197,"about_ca_topic_score_gemma":0.0006879865,"domain_scores_codex":[0.9995828,0.00005365147,0.000068399,0.00007330804,0.0001502377,0.00007160979],"domain_scores_gemma":[0.9997532,0.00003455772,0.00005266479,0.00005385728,0.00007448227,0.00003120113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003404086,0.000008262167,0.00007690197,0.00002258392,0.000006140174,0.00002600996,0.00001245395,0.00002510415,0.9994237,0.00003590839,0.00003135604,0.0002975078],"study_design_scores_gemma":[0.00001167549,0.00009606181,0.00190398,0.000007122954,0.00003932917,0.000302697,0.00003164256,0.00130739,0.9928599,0.00002021463,0.003413008,0.000006975611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807029,0.002152969,0.0114494,0.0002937475,0.0000826531,0.00008578185,0.001833448,0.0003178892,0.003081241],"genre_scores_gemma":[0.9745539,0.001912493,0.01241043,0.0001860256,0.00003083131,0.0001154113,0.005255649,0.0002401536,0.00529522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139423,"threshold_uncertainty_score":0.004761338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533504944945048,"score_gpt":0.2074750555646262,"score_spread":0.1921400061151757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}