{"id":"W2049128436","doi":"10.1089/adt.2007.120","title":"Functional Properties of <i>α</i> 7 Nicotinic Acetylcholine Receptors Co-expressed with RIC-3 in a Stable Recombinant CHO-K1 Cell Line","year":2008,"lang":"en","type":"article","venue":"Assay and Drug Development Technologies","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chinese hamster ovary cell; Nicotinic agonist; Acetylcholine receptor; Allosteric modulator; Allosteric regulation; Chemistry; Patch clamp; Receptor; Cell biology; Agonist; Biophysics; Heterologous expression; Biology; Biochemistry; Molecular biology; Recombinant DNA; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004515293,0.0003045176,0.0003808762,0.0001647386,0.0001526793,0.00001121868,0.0002776255,0.0002345276,0.00001163198],"category_scores_gemma":[0.000158578,0.0002291806,0.0000422446,0.0003070109,0.0003446307,0.00001797632,0.000304055,0.0002733625,0.00000722208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003819018,"about_ca_system_score_gemma":0.0003020085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002093411,"about_ca_topic_score_gemma":0.00007364106,"domain_scores_codex":[0.9982554,0.00006681341,0.0004983913,0.0005453146,0.0002408574,0.0003931891],"domain_scores_gemma":[0.9992272,0.00003145157,0.0002165219,0.0003590876,0.0001227397,0.00004302251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001097326,0.001897579,0.1997713,0.0002687856,0.000232707,0.000005176973,0.001309294,0.0002063955,0.7580366,0.00003442949,0.02028815,0.01685227],"study_design_scores_gemma":[0.001903706,0.0001722961,0.001215407,0.00008693992,0.00000920318,0.00001739565,0.00135824,0.000009782026,0.9549604,0.000009501395,0.03992454,0.0003325851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956745,0.002357981,0.0003518557,0.0003848778,0.0001157108,0.0005108531,0.000005123877,0.0001274834,0.0004716148],"genre_scores_gemma":[0.9890307,0.003662394,0.004378394,0.00003879225,0.00001980741,0.0001638947,0.00006742775,0.0000301315,0.002608463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1985559,"threshold_uncertainty_score":0.9345714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533504944945048,"score_gpt":0.2074750555646262,"score_spread":0.1921400061151757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}