{"id":"W2049128728","doi":"10.1093/nar/gkp1048","title":"An internal ribosomal entry site mediates redox-sensitive translation of Nrf2","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Cancer Institute; Rutgers Cancer Institute of New Jersey","keywords":"Biology; Translation (biology); Internal ribosome entry site; Translational regulation; Ribosome; Cell biology; Ribosomal protein; Protein biosynthesis; Untranslated region; Messenger RNA; Eukaryotic translation; Oxidative stress; Biochemistry; Molecular biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004303475,0.000133195,0.0001705836,0.00009749336,0.00007922317,0.00002701048,0.0002934898,0.000188023,0.00004586683],"category_scores_gemma":[0.0001210377,0.0001306745,0.00008560261,0.0001240992,0.0002700571,0.00001153592,0.00005910307,0.0002573845,0.00001930053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002227906,"about_ca_system_score_gemma":0.00006464257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002798997,"about_ca_topic_score_gemma":0.00001785332,"domain_scores_codex":[0.9984449,0.0002077359,0.0002415555,0.0003916641,0.0003447132,0.0003694959],"domain_scores_gemma":[0.9990653,0.00003602127,0.00006013723,0.0003543461,0.0003358287,0.0001483518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004162367,0.0001354908,0.00362861,0.00001178238,0.00002628061,0.000004554454,0.0005004479,0.00001019745,0.9842909,0.00006013798,0.0005135983,0.01040176],"study_design_scores_gemma":[0.0005962341,0.0008508748,0.02794878,0.00002314616,0.000006471167,0.000005616971,0.0002984669,0.0002422943,0.9679994,0.0005103149,0.001381507,0.0001368869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941757,0.000302358,0.0005404727,0.0002493449,0.00004718648,0.0001817751,0.00007455138,0.000009939929,0.004418665],"genre_scores_gemma":[0.9976104,0.0002292234,0.0012714,0.00007268411,0.000397221,0.000004517658,0.0002557776,0.0000170805,0.0001416279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02432017,"threshold_uncertainty_score":0.532875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02329627541167166,"score_gpt":0.32982699961006,"score_spread":0.3065307241983883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}