{"id":"W2049142811","doi":"10.1242/jcs.098889","title":"LRP1 mediates the Shh-induced endocytosis of the GPC3-Shh complex","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Endocytosis; Cell biology; LRP1; Genetics; Endocrinology; Receptor; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008666549,0.00006601939,0.00009292916,0.00002855398,0.0001327761,0.00001491618,0.0005566179,0.00003776227,0.00003250397],"category_scores_gemma":[0.00004925491,0.00003340811,0.0001234268,0.0001835904,0.0002839603,0.00001340535,0.00005390236,0.0001004762,0.000001599644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001050726,"about_ca_system_score_gemma":0.0001228397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007046795,"about_ca_topic_score_gemma":0.000006517788,"domain_scores_codex":[0.9990978,0.00003845213,0.0002293923,0.00007473413,0.000369005,0.0001906275],"domain_scores_gemma":[0.9993017,0.00001649482,0.0002622617,0.0001991775,0.0001400083,0.00008032993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001258993,0.000035802,0.00829276,0.000004028425,0.000004809754,2.842054e-7,0.0002007513,0.00000915778,0.9910848,0.00003136669,0.00006544681,0.0002582403],"study_design_scores_gemma":[0.0001570822,0.0000826116,0.04853718,0.000006555798,0.00001983867,0.00002093887,0.0001441669,0.00002726123,0.9412479,0.00002392646,0.009686586,0.00004596428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968261,0.0004866968,0.0006210898,0.0003000685,0.0003770865,0.00005527758,0.000001642725,8.21996e-7,0.001331208],"genre_scores_gemma":[0.9992968,0.0001211637,0.0001595356,0.0001120454,0.000234524,5.054799e-7,0.000003098927,0.000003842853,0.00006843946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04983687,"threshold_uncertainty_score":0.1362343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211052321122882,"score_gpt":0.2466164421280273,"score_spread":0.2255112100157391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}