{"id":"W2049145862","doi":"10.1182/blood-2008-02-142687","title":"Cyproheptadine displays preclinical activity in myeloma and leukemia","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Cyproheptadine; Cancer research; Leukemia; Multiple myeloma; Pharmacology; Medicine; Biology; Internal medicine; Receptor; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003048321,0.0003157869,0.0005890898,0.0005646715,0.0002623661,0.0003042244,0.0002740058,0.0003236191,0.002805291],"category_scores_gemma":[0.0002367287,0.0001657891,0.0002664918,0.0005699763,0.0001987517,0.0002014846,0.0001861248,0.0006566319,0.0003476148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003998238,"about_ca_system_score_gemma":0.0004277089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001444874,"about_ca_topic_score_gemma":0.003761482,"domain_scores_codex":[0.9998748,0.00002662844,0.000009947448,0.00002268525,0.00003563572,0.00003034592],"domain_scores_gemma":[0.9998305,0.0000319299,0.00003257721,0.00001937764,0.00003451073,0.00005112276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003131398,0.001643734,0.001697355,0.0002914349,0.00008379608,0.0002362107,0.00006706615,0.001354957,0.9468801,0.0004487127,0.001313484,0.04285176],"study_design_scores_gemma":[0.001082026,0.03277953,0.01475546,0.00002751546,0.0001993185,0.0007627634,0.00003691043,0.001258273,0.9234445,0.0001923396,0.02544256,0.0000187659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687057,0.01617378,0.003312394,0.0005396391,0.0001187406,0.0004780158,0.002372476,0.0003514707,0.007947696],"genre_scores_gemma":[0.975379,0.01167917,0.003324189,0.0002247062,0.00005429164,0.0001490387,0.003240131,0.00003855662,0.005910922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002805291,"threshold_uncertainty_score":0.009384632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02474019517815354,"score_gpt":0.2763561640633495,"score_spread":0.251615968885196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}