{"id":"W2049167941","doi":"10.1007/s10549-014-3050-3","title":"ERβ splice variant expression in four large cohorts of human breast cancer patient tumors","year":2014,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Institutes of Health","keywords":"Breast cancer; Estrogen receptor; Cancer research; Biomarker; Gene knockdown; Context (archaeology); Oncology; Cancer; RNA splicing; Medicine; Alternative splicing; splice; Triple-negative breast cancer; Immunohistochemistry; Biology; Internal medicine; Gene isoform; Genetics; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041096,0.0002044205,0.0003369923,0.0007554956,0.0005073722,0.0007854825,0.0002593874,0.000265773,0.001139056],"category_scores_gemma":[0.001219826,0.0002077709,0.0002713312,0.0008311761,0.0003072717,0.0002266813,0.0004994175,0.000266859,0.0002412799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002842401,"about_ca_system_score_gemma":0.0001746004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002540787,"about_ca_topic_score_gemma":0.002366847,"domain_scores_codex":[0.9996846,0.00007373698,0.00002689972,0.0001111015,0.00005026292,0.00005333898],"domain_scores_gemma":[0.9994258,0.0001609711,0.0001292677,0.0001091612,0.00009686838,0.000078007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001427528,0.00003928408,0.9804323,0.00001411813,0.0001718291,0.0003637373,0.0003051907,0.0001168688,0.01240003,0.00008118152,0.0003530638,0.004294928],"study_design_scores_gemma":[0.00003530154,0.0001216173,0.9945952,0.000003487648,0.0001102292,0.001763938,0.0003668654,0.000196358,0.001686674,0.00009255292,0.001019916,0.000007870569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991714,0.0001282422,0.00009790711,0.00001644554,0.000002444266,0.000003117118,0.0004234957,0.000003959234,0.0001530778],"genre_scores_gemma":[0.9977778,0.0001201822,0.00008290299,0.00002647932,0.000005903622,0.000008710704,0.001644113,0.00001060699,0.000323291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002540787,"threshold_uncertainty_score":0.00505197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412881907505673,"score_gpt":0.3131417675354952,"score_spread":0.2990129484604385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}