{"id":"W2049207446","doi":"10.1073/pnas.252342899","title":"RNA interference-mediated silencing of <i>Sod2</i> in <i>Drosophila</i> leads to early adult-onset mortality and elevated endogenous oxidative stress","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; York University","funders":"","keywords":"SOD2; Oxidative stress; Biology; Reactive oxygen species; Superoxide dismutase; Mitochondrion; SOD1; Mitochondrial ROS; Cell biology; Respiratory chain; Citric acid cycle; Oxidative phosphorylation; Biochemistry; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004553833,0.0001138442,0.0001739247,0.0001031284,0.00006552238,0.00001371433,0.0005134286,0.0001007187,0.000004780636],"category_scores_gemma":[0.0005267533,0.0000906327,0.00003986002,0.0003786647,0.0005380453,0.00002312634,0.0001846446,0.0001148326,5.354891e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001256633,"about_ca_system_score_gemma":0.00001943856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006222575,"about_ca_topic_score_gemma":0.000003469201,"domain_scores_codex":[0.9987156,0.00001287277,0.0003484559,0.0002899941,0.0004656261,0.0001674283],"domain_scores_gemma":[0.9992942,0.00003478237,0.0002886995,0.0000186899,0.0003162551,0.00004733184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001258114,0.00005473731,0.06918602,0.00004210026,0.00001244628,1.293222e-8,0.001027179,0.0001103744,0.9293238,0.0001475105,0.00004951454,0.00003372214],"study_design_scores_gemma":[0.0001821815,0.0001676736,0.08336004,0.0000708271,0.000008980939,0.000004124556,0.0002038115,0.0003046268,0.9146952,0.0009101927,0.000002849983,0.00008951084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987116,0.0001858564,0.000003213011,0.0003576117,0.00001422395,0.0001807352,0.00007920101,0.00000334317,0.0004642445],"genre_scores_gemma":[0.9992005,0.0001842741,0.0003317939,0.0002180943,0.0000316724,0.000007012519,9.769208e-7,0.000004993552,0.00002073115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01462862,"threshold_uncertainty_score":0.3695894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04925168164700814,"score_gpt":0.2752372352481268,"score_spread":0.2259855536011186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}