{"id":"W2049211399","doi":"10.1161/01.cir.0000147773.86866.cd","title":"Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Formation in Injured Arteries by a Novel, Oral Mitogen-Activated Protein Kinase/Extracellular Signal–Regulated Kinase Inhibitor","year":2004,"lang":"en","type":"article","venue":"Circulation","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Medicine; Vascular smooth muscle; Kinase; Neointima; Cell growth; Protein kinase A; Mitogen-activated protein kinase; Endocrinology; Cell biology; Internal medicine; Biology; Biochemistry; Restenosis; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789937,0.000187597,0.0001782212,0.0001233094,0.00007497073,0.00003662497,0.00004239329,0.0002422451,0.000007584323],"category_scores_gemma":[0.00002855667,0.000205478,0.00005863578,0.0001989346,0.00005903331,0.00006754907,0.00002868019,0.00008379467,0.00000169172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005208248,"about_ca_system_score_gemma":0.00005823775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006164941,"about_ca_topic_score_gemma":0.00003152408,"domain_scores_codex":[0.9988168,0.00007177892,0.0004120698,0.0003241044,0.0001822669,0.0001930021],"domain_scores_gemma":[0.9994087,0.000003109535,0.0002127922,0.0001856546,0.0001293269,0.00006044966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001237453,0.0001889445,0.0004030268,0.0001182704,0.000008331634,0.00000224815,0.0003760776,0.0007148198,0.9960625,0.00006051666,0.00001560149,0.001925964],"study_design_scores_gemma":[0.002463227,0.0002524044,0.01023369,0.00007942133,0.00001717011,0.000003121535,0.00008171104,0.001111622,0.9849984,0.0001640834,0.0003732517,0.0002218696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728839,0.0003342521,0.02573549,0.00003604988,0.00004738322,0.0008856539,0.00003241926,0.00002175538,0.00002309624],"genre_scores_gemma":[0.9975984,0.000008173977,0.0006862685,0.00001696406,0.0000567706,0.00007635415,0.001522191,0.00002422866,0.00001068264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02504922,"threshold_uncertainty_score":0.8379148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00825379092483082,"score_gpt":0.1966746773098796,"score_spread":0.1884208863850488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}