{"id":"W2049211399","doi":"10.1161/01.cir.0000147773.86866.cd","title":"Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Formation in Injured Arteries by a Novel, Oral Mitogen-Activated Protein Kinase/Extracellular Signal–Regulated Kinase Inhibitor","year":2004,"lang":"en","type":"article","venue":"Circulation","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"MAPK/ERK pathway; Medicine; Vascular smooth muscle; Kinase; Neointima; Cell growth; Protein kinase A; Mitogen-activated protein kinase; Endocrinology; Cell biology; Internal medicine; Biology; Biochemistry; Restenosis; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056139,0.0006232763,0.0004462022,0.0002934098,0.0001227263,0.0002149734,0.0002647879,0.0002604095,0.0009520289],"category_scores_gemma":[0.00007966724,0.0001507659,0.0003902054,0.0001625573,0.0002027666,0.0002047307,0.0001534621,0.0007206241,0.000252085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066131,"about_ca_system_score_gemma":0.0002338975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001884072,"about_ca_topic_score_gemma":0.0004515467,"domain_scores_codex":[0.9999366,0.000007732567,0.000009093465,0.00001576087,0.0000144872,0.00001626167],"domain_scores_gemma":[0.9999619,0.000004560207,0.00001503367,0.000003557177,0.000003611451,0.00001141567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001681617,0.0007345068,0.0002996871,0.000323956,0.00003611497,0.0001115709,0.00001885342,0.0002987375,0.9842924,0.0001187976,0.0001271321,0.01195658],"study_design_scores_gemma":[0.00112294,0.01022743,0.005786357,0.00002329842,0.0001770819,0.0006424002,0.00002300087,0.001342928,0.9772403,0.00005148539,0.003350426,0.00001243743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928697,0.003081339,0.002465792,0.00005132032,0.00004366803,0.00009995893,0.0002743755,0.00007374708,0.001040184],"genre_scores_gemma":[0.9910348,0.003179187,0.003612743,0.00004550539,0.00003501005,0.0001446812,0.0005052004,0.000008764498,0.001434233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009520289,"threshold_uncertainty_score":0.003184855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00825379092483082,"score_gpt":0.1966746773098796,"score_spread":0.1884208863850488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}