{"id":"W2049219670","doi":"10.3899/jrheum.081115","title":"Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Takeda Science Foundation","keywords":"Gene knockdown; Histone deacetylase 2; Cell growth; HDAC1; Apoptosis; Molecular biology; Cancer research; Medicine; Synovial membrane; Small interfering RNA; Downregulation and upregulation; Biology; Arthritis; Immunology; Histone; Histone deacetylase; Transfection; Cell culture; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000284087,0.0003679833,0.0002855247,0.0002430448,0.0001822053,0.0003216974,0.0001612505,0.0002565494,0.000753389],"category_scores_gemma":[0.0001496432,0.0001222682,0.0003108519,0.000216581,0.0001945835,0.0001916645,0.0001056028,0.0002497592,0.0002925603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512959,"about_ca_system_score_gemma":0.000219249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009491439,"about_ca_topic_score_gemma":0.001406354,"domain_scores_codex":[0.9997754,0.00002286221,0.00002895538,0.0000557319,0.00007696058,0.00004011918],"domain_scores_gemma":[0.9998969,0.00001803347,0.00003196493,0.00001026157,0.00002711504,0.00001578567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229538,0.00001774581,0.0009877485,0.0001326802,0.00001416772,0.00008459694,0.00002301385,0.00003794216,0.9955208,0.00003508571,0.00003296938,0.002990322],"study_design_scores_gemma":[0.00005957782,0.0007666365,0.02610547,0.00002722087,0.0001024913,0.00099616,0.0001291767,0.0007881473,0.9653804,0.00005712776,0.005571089,0.00001647061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543662,0.03734547,0.005090064,0.0002007674,0.00008185796,0.00005055994,0.0007677101,0.00006960497,0.002027661],"genre_scores_gemma":[0.9860989,0.008224502,0.003161011,0.00007559224,0.00003620024,0.00004928413,0.0005881847,0.000009586931,0.001756739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009491439,"threshold_uncertainty_score":0.002548814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007207672139088317,"score_gpt":0.2687975871085464,"score_spread":0.2615899149694581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}