{"id":"W2049219670","doi":"10.3899/jrheum.081115","title":"Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts","year":2009,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Takeda Science Foundation","keywords":"Gene knockdown; Histone deacetylase 2; Cell growth; HDAC1; Apoptosis; Molecular biology; Cancer research; Medicine; Synovial membrane; Small interfering RNA; Downregulation and upregulation; Biology; Arthritis; Immunology; Histone; Histone deacetylase; Transfection; Cell culture; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005920138,0.000114645,0.0003150699,0.0001553145,0.00005538066,0.000005264755,0.0001750653,0.0001429419,0.00001694452],"category_scores_gemma":[0.0002894116,0.00008593128,0.0000638822,0.000101608,0.0002127822,0.00001086606,0.00005781205,0.0002189955,0.000002219259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002191202,"about_ca_system_score_gemma":0.0001082073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004932793,"about_ca_topic_score_gemma":0.00009825084,"domain_scores_codex":[0.9986885,0.0002688065,0.0005416234,0.00011874,0.0001841934,0.000198172],"domain_scores_gemma":[0.9991886,0.0000807937,0.0003430819,0.0001928056,0.0001279383,0.00006678389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001314097,0.0001105044,0.003352659,0.00001944737,0.00002011915,0.00000613471,0.0002197091,0.00009520123,0.9830711,0.000064167,0.004219457,0.007507393],"study_design_scores_gemma":[0.004023107,0.00382144,0.008845506,0.0007748167,0.00001255608,0.006879872,0.0003848471,0.00005489745,0.9700742,0.0005033942,0.00437921,0.0002461016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913827,0.007454114,0.0005668706,0.0003042702,0.0001323769,0.00008165833,0.000002398577,0.000002596151,0.00007302019],"genre_scores_gemma":[0.9922441,0.007462351,0.0002050482,0.00002893193,0.00001572016,0.000001094889,0.000003205188,0.00000955637,0.00003002488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01299686,"threshold_uncertainty_score":0.3504176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007207672139088317,"score_gpt":0.2687975871085464,"score_spread":0.2615899149694581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}