{"id":"W2049247975","doi":"10.1074/jbc.m113.513879","title":"The Diarylheptanoid Hirsutenone Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin via Modulation of Apoptosis-inducing Factor and X-linked Inhibitor of Apoptosis","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Apoptosis; Cisplatin; Cancer research; PI3K/AKT/mTOR pathway; Proteasome inhibitor; Cell culture; Inhibitor of apoptosis; Programmed cell death; Protein kinase B; Biology; Bortezomib; Ovarian cancer; Cancer; Pharmacology; Chemistry; Chemotherapy; Medicine; Internal medicine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006313869,0.0001965923,0.0002044677,0.0002050886,0.00007374069,0.0001152897,0.0001273442,0.0001454515,0.001132881],"category_scores_gemma":[0.00006920263,0.00007175899,0.000179478,0.0001840813,0.00009703838,0.0001356066,0.0001207444,0.0002949386,0.0001388016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001026569,"about_ca_system_score_gemma":0.0001158957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002997581,"about_ca_topic_score_gemma":0.0008992215,"domain_scores_codex":[0.9999483,0.000008782577,0.000007173616,0.00001050476,0.0000134104,0.00001186657],"domain_scores_gemma":[0.9999663,0.00000625197,0.000009627503,0.00000632808,0.000005436698,0.000006033443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001605473,0.00005209142,0.0002400984,0.00005454971,0.000005137215,0.00004314122,0.000009302179,0.00007839098,0.9961588,0.00003169621,0.00001778949,0.003148391],"study_design_scores_gemma":[0.0000705975,0.002443715,0.007915728,0.000008347054,0.00002258397,0.0002394041,0.00003124838,0.000420279,0.9865715,0.0000502736,0.002220903,0.000005515167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958439,0.001818985,0.0009410367,0.00004187957,0.00002265274,0.00005069057,0.0001760049,0.00003102354,0.001073618],"genre_scores_gemma":[0.9966177,0.0009605144,0.0009307547,0.00004779065,0.000006464949,0.00002685416,0.0002379048,0.000004001214,0.001167992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132881,"threshold_uncertainty_score":0.003789842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269630250139063,"score_gpt":0.2334337370240185,"score_spread":0.2207374345226278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}