{"id":"W2049258047","doi":"10.1016/j.mrfmmm.2003.08.002","title":"Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline by Salmonella typhimurium TA1538 co-expressing human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and cytochrome b5","year":2003,"lang":"en","type":"article","venue":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health and Welfare; Korea University; University of Calgary","keywords":"Naringenin; CYP1A2; Chemistry; Quinoline; Biochemistry; Mutagenesis; Mutagen; Cytochrome b5; Quercetin; Cytochrome P450; Enzyme; Mutant; Carcinogen; Antioxidant; Flavonoid; Gene; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331903,0.0002820905,0.0002335069,0.0001355002,0.00008641168,0.0001740721,0.0002380332,0.0003310702,0.002632349],"category_scores_gemma":[0.0002712053,0.0001887998,0.0002457033,0.0001055851,0.0002067573,0.0001839045,0.0001277712,0.0004240064,0.0004764689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128633,"about_ca_system_score_gemma":0.0002259517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001666366,"about_ca_topic_score_gemma":0.00225067,"domain_scores_codex":[0.9998618,0.00003630152,0.00001043927,0.00001972321,0.00002206219,0.0000495788],"domain_scores_gemma":[0.9997798,0.00007597773,0.00003782685,0.00002379672,0.00002933843,0.00005341491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002406114,0.00008044798,0.0001415631,0.00002977157,0.000007386803,0.00004636847,0.00002237941,0.0001342525,0.9954087,0.0001218385,0.0001029368,0.001498199],"study_design_scores_gemma":[0.0001472677,0.002418403,0.008463625,0.000009505673,0.00002482629,0.0001234304,0.0000606128,0.0009668272,0.9867127,0.00009811555,0.0009612323,0.00001352382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962268,0.001229988,0.000437896,0.000102156,0.00004431805,0.0000241292,0.0004437458,0.00004269185,0.001448319],"genre_scores_gemma":[0.9964929,0.0004253043,0.0004617726,0.0000504748,0.00001155215,0.00001967352,0.0005005138,0.00001027887,0.002027472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002632349,"threshold_uncertainty_score":0.008806109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06792987090676106,"score_gpt":0.405054574289843,"score_spread":0.3371247033830819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}