{"id":"W2049273083","doi":"10.1039/b822794b","title":"Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides","year":2009,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Herman Frasch Foundation for Chemical Research; Canadian Association for the Study of the Liver; National Science Foundation","keywords":"Pyrococcus furiosus; Chemistry; Mannose; Biocatalysis; Biochemistry; Sugar; Nucleotide; Hyperthermophile; Isomerase; Thermostability; Enzyme; Gene; Catalysis; Reaction mechanism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175845,0.0003852689,0.0002728316,0.0002069094,0.0001672934,0.0002937451,0.0002109225,0.0002411978,0.000323398],"category_scores_gemma":[0.000146007,0.000141133,0.0001238089,0.0002454898,0.0001993019,0.0002358728,0.0001984822,0.0003348317,0.0002583417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004408747,"about_ca_system_score_gemma":0.0004645835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406142,"about_ca_topic_score_gemma":0.00111093,"domain_scores_codex":[0.9998387,0.00001746078,0.00001278992,0.00003439109,0.00006904925,0.00002764321],"domain_scores_gemma":[0.9999508,0.000005568512,0.00001084788,0.000009754717,0.00000973147,0.00001327688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002939324,0.00001331402,0.0003244932,0.00002542177,0.00000204698,0.00004326951,0.00001047898,0.0001022919,0.9974427,0.00006094587,0.00001627943,0.001929344],"study_design_scores_gemma":[0.000005658766,0.00006209284,0.002219168,0.000002904578,0.000008291309,0.0004035664,0.00001373946,0.000500048,0.9954816,0.00004938826,0.001249337,0.000004125061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944206,0.001110874,0.003410421,0.00009450444,0.000009692299,0.00002159228,0.0003017571,0.00004821753,0.0005823002],"genre_scores_gemma":[0.9895368,0.0006304136,0.008059788,0.00002330224,0.000005272645,0.00002015729,0.000765466,0.00002132576,0.000937563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001406142,"threshold_uncertainty_score":0.003198802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006894422127012446,"score_gpt":0.2078014519729474,"score_spread":0.200907029845935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}