{"id":"W2049285731","doi":"10.1371/journal.ppat.1003241","title":"Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; Canadian Institutes of Health Research; Ontario HIV Treatment Network; University of Ottawa; Université Laval","keywords":"Digoxin; Viral replication; RNA; Small interfering RNA; Biology; RNA splicing; In vitro; Viral load; Virology; Human immunodeficiency virus (HIV); Virus; Medicine; Genetics; Gene; Internal medicine; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00006087465,0.0001282633,0.0001455913,0.00004706845,0.0001950969,0.00004371285,0.0001492191,0.00009393437,0.0009822348],"category_scores_gemma":[0.0000732586,0.0001049854,0.00004205771,0.00006422753,0.00007838064,0.0001650039,0.0000665487,0.0001352088,0.006100506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003877651,"about_ca_system_score_gemma":0.00003084444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004199495,"about_ca_topic_score_gemma":0.000002076953,"domain_scores_codex":[0.9989883,0.00007896429,0.0001654915,0.0003377977,0.00004321396,0.0003862793],"domain_scores_gemma":[0.9994342,0.00004051397,0.00005506141,0.00036052,0.00006787609,0.0000418624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001348385,0.0001969328,0.003319386,0.0000238215,0.00005907573,0.000004059917,0.0001834284,4.792925e-7,0.9630875,0.00001047438,0.01052833,0.02257301],"study_design_scores_gemma":[0.0006292435,0.0001368229,0.005518498,0.00003543083,0.00002974793,0.00001804909,0.00009038491,0.00003629064,0.9774593,0.0000714803,0.01580778,0.0001670271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942233,0.001923938,0.0002355588,0.0004868189,0.00004287848,0.000404534,0.0002643559,0.0001203596,0.002298262],"genre_scores_gemma":[0.9948803,0.00006611342,0.0002259931,0.00005784196,0.00002514865,0.0002832882,0.0008633563,0.00001845963,0.003579507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02240598,"threshold_uncertainty_score":0.999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673491055466271,"score_gpt":0.2485256323448071,"score_spread":0.2317907217901443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}