{"id":"W2049300936","doi":"10.1016/j.bmcl.2004.10.040","title":"2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Ryerson University; University of Minnesota; Eli Lilly and Company","keywords":"Chemistry; Steric effects; Methylene; Stereochemistry; Metabotropic glutamate receptor; Ligand (biochemistry); Ethylene; Amino acid; Metabotropic receptor; Receptor; Glutamate receptor; Medicinal chemistry; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867152,0.0002160134,0.0003095011,0.0001226776,0.0001559907,0.0001901394,0.0005526427,0.0004450404,0.002652028],"category_scores_gemma":[0.0002302754,0.0001295272,0.0001551919,0.0001655165,0.0002082021,0.000322553,0.0002002056,0.000518423,0.0004507618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603351,"about_ca_system_score_gemma":0.000224708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004442294,"about_ca_topic_score_gemma":0.0006493856,"domain_scores_codex":[0.9998707,0.0000410926,0.000009915705,0.00001755988,0.00002058082,0.00004021092],"domain_scores_gemma":[0.9999015,0.00001774471,0.00002474646,0.00001402174,0.000009476608,0.00003230568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001952863,0.00009328491,0.0001024279,0.00008718093,0.00001319271,0.0002654881,0.00004653127,0.0006038342,0.9919036,0.001136601,0.0001151664,0.003679667],"study_design_scores_gemma":[0.0004987425,0.003325971,0.001441652,0.00001587142,0.00003007094,0.0005200087,0.00004776396,0.00192376,0.9844483,0.0002312643,0.007491691,0.00002496778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919841,0.001190815,0.001614686,0.0001217081,0.0001223408,0.00004064693,0.0001671401,0.00004550933,0.004712952],"genre_scores_gemma":[0.9940599,0.0007534915,0.001860673,0.0001201723,0.00002187574,0.0000345765,0.0002525381,0.00001461508,0.002882066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002652028,"threshold_uncertainty_score":0.008871913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02005490888989953,"score_gpt":0.2581057808839127,"score_spread":0.2380508719940131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}