{"id":"W2049302457","doi":"10.1089/104303401753204544","title":"Inhibition of Carcinoma Cell Growth and Metastasis by a Vesicular Stomatitis Virus G-Pseudotyped Retrovector Expressing Type I Insulin-Like Growth Factor Receptor Antisense","year":2001,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Vesicular stomatitis virus; Biology; Genetic enhancement; Cancer research; Viral vector; Murine leukemia virus; Growth factor; Virology; Transduction (biophysics); Metastasis; Molecular biology; Green fluorescent protein; Cell culture; Long terminal repeat; Virus; Receptor; Cancer; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844487,0.0003649971,0.0002032378,0.0001758602,0.000105486,0.0002800828,0.0001714204,0.0001923265,0.0006460496],"category_scores_gemma":[0.0001032397,0.0001184238,0.0001766676,0.0001013916,0.0002185659,0.000131934,0.0001278474,0.0004213736,0.000245545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003269067,"about_ca_system_score_gemma":0.0003562803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022295,"about_ca_topic_score_gemma":0.001427655,"domain_scores_codex":[0.9998764,0.00002244269,0.00001105561,0.00002312023,0.0000419375,0.00002497362],"domain_scores_gemma":[0.9999392,0.00001654268,0.00001550344,0.000007707599,0.000007119728,0.00001385463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002883186,0.00001712621,0.00004214298,0.00001056026,0.000001679618,0.00001371397,0.000004904878,0.00005338128,0.9990911,0.0001618366,0.00001603107,0.00055865],"study_design_scores_gemma":[0.00001597919,0.0002761127,0.0005516959,0.000001772514,0.000006211553,0.00008946372,0.000007073279,0.001015774,0.9967484,0.00002595372,0.001259638,0.000001976381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894203,0.0009921636,0.007529602,0.00007457752,0.00004518143,0.00007168897,0.0001959925,0.0001346804,0.001535758],"genre_scores_gemma":[0.9881828,0.0007987272,0.006710685,0.00002390597,0.000008234788,0.00006322668,0.0003993451,0.00002927432,0.003783764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022295,"threshold_uncertainty_score":0.002371848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235764704021769,"score_gpt":0.2690030848890136,"score_spread":0.2466454378487959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}