{"id":"W2049314466","doi":"10.1074/jbc.m300327200","title":"Vpu Exerts a Positive Effect on HIV-1 Infectivity by Down-modulating CD4 Receptor Molecules at the Surface of HIV-1-producing Cells","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Infectivity; Glycoprotein; Mutant; Virology; Biology; Virus; Viral entry; Cell biology; Receptor; Viral replication; Gene; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066863,0.0004336545,0.0002507379,0.000207544,0.0001429974,0.0003944865,0.0002361,0.0001950756,0.0007854878],"category_scores_gemma":[0.0001858323,0.0001193923,0.0001920639,0.00007668095,0.0002020317,0.0001443927,0.0002190198,0.0003776514,0.0002279809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933873,"about_ca_system_score_gemma":0.0001446213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000276609,"about_ca_topic_score_gemma":0.0002315572,"domain_scores_codex":[0.9998614,0.00003834971,0.00001319905,0.000019685,0.00003219523,0.00003519805],"domain_scores_gemma":[0.9998939,0.00003667785,0.00001808743,0.00001771112,0.00000996147,0.00002351557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006854442,0.0000203112,0.0001405171,0.00002368222,0.000003390644,0.00003387078,0.000006528735,0.00003200155,0.9982044,0.00006809739,0.00001042843,0.001388394],"study_design_scores_gemma":[0.00001054778,0.0003220352,0.003526553,0.000004645344,0.00001220261,0.0001907431,0.00001180648,0.0004822645,0.9940876,0.00003738351,0.001311793,0.000002431074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968296,0.001567489,0.000609301,0.0000346855,0.00001735214,0.000008334299,0.00005324227,0.00003572912,0.0008442665],"genre_scores_gemma":[0.9964337,0.0009498117,0.00117218,0.00002824976,0.00001877033,0.00001475455,0.000156375,0.00001296605,0.001213162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007854878,"threshold_uncertainty_score":0.00262773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009582827129144584,"score_gpt":0.2435543178566326,"score_spread":0.233971490727488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}