{"id":"W2049314466","doi":"10.1074/jbc.m300327200","title":"Vpu Exerts a Positive Effect on HIV-1 Infectivity by Down-modulating CD4 Receptor Molecules at the Surface of HIV-1-producing Cells","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Infectivity; Glycoprotein; Mutant; Virology; Biology; Virus; Viral entry; Cell biology; Receptor; Viral replication; Gene; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008064704,0.0002110597,0.0004330748,0.00001666058,0.0001734225,0.00001027616,0.0001800458,0.0002591927,0.0007004364],"category_scores_gemma":[0.000697901,0.0001096953,0.0002286621,0.00009542561,0.0002987598,0.00003021857,0.00007496843,0.000552851,0.0001397788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014334,"about_ca_system_score_gemma":0.00004380494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001009007,"about_ca_topic_score_gemma":4.984964e-7,"domain_scores_codex":[0.9983252,0.0006212306,0.0003623753,0.0002599809,0.00008537449,0.0003458714],"domain_scores_gemma":[0.9981976,0.001054297,0.0003689111,0.0002139682,0.0001058034,0.00005946432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005298808,0.0003046787,0.01124869,0.00002350824,0.0002206077,0.00001627863,0.00006594943,0.0001119133,0.9808947,0.000001664499,0.005826411,0.0007557544],"study_design_scores_gemma":[0.001100674,0.0009889841,0.001437551,0.00008367098,0.00002638,0.0001247727,0.00004129386,9.82432e-7,0.9940016,0.00001175292,0.002072165,0.0001101658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960254,0.002107905,0.00004883761,0.0002384407,0.00008832876,0.0001574206,0.0001891278,0.000009103637,0.001135418],"genre_scores_gemma":[0.998862,0.0001390438,0.0000795558,0.00002764827,0.00002681526,0.00000373698,0.0000789767,0.000008083348,0.0007741418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01310695,"threshold_uncertainty_score":0.7669287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009582827129144584,"score_gpt":0.2435543178566326,"score_spread":0.233971490727488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}