{"id":"W2049334581","doi":"10.1523/jneurosci.1305-11.2012","title":"Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin","year":2012,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"CHDI Foundation; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Johns Hopkins University","keywords":"Huntingtin; Genetically modified mouse; Biology; Huntington's disease; Huntingtin Protein; Pathogenesis; Transgene; Trinucleotide repeat expansion; Cleavage (geology); Mutant; Molecular biology; Genetics; Cell biology; Gene; Immunology; Allele; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004409292,0.0009787187,0.0006950742,0.001151093,0.0006155795,0.0005493477,0.000902276,0.002204728,0.006252173],"category_scores_gemma":[0.000222314,0.0005515469,0.0006962105,0.0005727572,0.0007199185,0.0007915575,0.0004353892,0.003029275,0.002674459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006680182,"about_ca_system_score_gemma":0.0004397092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008047206,"about_ca_topic_score_gemma":0.001091856,"domain_scores_codex":[0.9994869,0.00005231063,0.00006686951,0.0001905827,0.0001090077,0.00009429708],"domain_scores_gemma":[0.999619,0.00004336971,0.0001101831,0.00005185706,0.00005238869,0.0001231214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008609734,0.001291136,0.0005389869,0.0001243172,0.00003951197,0.0005981469,0.0001241361,0.0001510434,0.9915649,0.001073523,0.0007731366,0.002860173],"study_design_scores_gemma":[0.001566496,0.01324575,0.009956289,0.0002280401,0.0004574927,0.008044384,0.0003404327,0.005190476,0.9074263,0.001805709,0.05161726,0.0001215255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605594,0.003041137,0.01940215,0.001375628,0.0007455156,0.0008949209,0.005614381,0.00136964,0.006997353],"genre_scores_gemma":[0.9059515,0.005176197,0.02298259,0.001035952,0.0002318501,0.002755391,0.009640616,0.000309077,0.05191687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006252173,"threshold_uncertainty_score":0.02091557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07027249473865321,"score_gpt":0.300166512437773,"score_spread":0.2298940176991198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}