{"id":"W2049368206","doi":"10.1186/s12915-014-0081-5","title":"Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression","year":2014,"lang":"en","type":"article","venue":"BMC Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Lister Institute of Preventive Medicine; European Molecular Biology Laboratory; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"NODAL; Endoderm; Biology; Mesoderm; Zebrafish; FGF and mesoderm formation; Nodal signaling; Cell biology; Blastula; Germ layer; Polarity in embryogenesis; Genetics; Ectoderm; Gastrulation; Embryogenesis; Embryo; Cellular differentiation; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005974883,0.0001335844,0.0002868194,0.00009328467,0.0000278666,0.000004371938,0.00008782445,0.0003137127,0.000002015807],"category_scores_gemma":[0.0001261728,0.000129343,0.00003996199,0.0001108522,0.0001794298,0.00001076391,0.00007680203,0.00004528169,8.940499e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000126615,"about_ca_system_score_gemma":0.00004833847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007945655,"about_ca_topic_score_gemma":0.001461822,"domain_scores_codex":[0.9986012,0.0001857878,0.0005502483,0.0004144694,0.00004401363,0.0002042652],"domain_scores_gemma":[0.9995335,0.00006750117,0.0001886037,0.0001398549,0.00004123756,0.00002923891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003079191,0.00006267343,0.3318971,0.00004758255,0.00000611507,1.480484e-7,0.00005367058,0.0001873955,0.6665698,0.0001823829,0.00001050483,0.000674723],"study_design_scores_gemma":[0.001691374,0.00007994131,0.612606,0.00004202648,0.00000398714,0.00001100406,0.00004259682,0.001630867,0.3806638,0.0030723,0.00005548081,0.0001005377],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838471,0.001863175,0.01373202,0.00005097837,0.00008323587,0.0003437596,0.00005658871,0.000003178603,0.00001996253],"genre_scores_gemma":[0.995293,0.0001058544,0.004051339,0.00002925728,0.00003006483,0.00006713817,0.0003962622,0.000006584806,0.00002048873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.285906,"threshold_uncertainty_score":0.5274454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068254069454826,"score_gpt":0.2547731512326869,"score_spread":0.2440906105381386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}