{"id":"W2049387039","doi":"10.1046/j.1538-7836.2003.00050.x","title":"von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function","year":2003,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Blood Services; St. Michael's Hospital","funders":"","keywords":"Platelet; Von Willebrand factor; Thrombin; Cell biology; Chemistry; Platelet activation; Function (biology); Coagulation; Signal transduction; Platelet Glycoprotein GPIb-IX Complex; Transmembrane protein; Phosphatase; Biochemistry; Internal medicine; Enzyme; Receptor; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002811462,0.0003783097,0.0002387262,0.0001802489,0.0001904722,0.0006942135,0.0001983591,0.0006691173,0.001663306],"category_scores_gemma":[0.0002950328,0.0001449884,0.0004588604,0.0001529294,0.0002998032,0.0006388211,0.0002887127,0.0006377815,0.0006496255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003198198,"about_ca_system_score_gemma":0.0001810751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004329046,"about_ca_topic_score_gemma":0.0002811157,"domain_scores_codex":[0.9997771,0.00005917943,0.00001592992,0.00003596246,0.00004391157,0.0000678513],"domain_scores_gemma":[0.9999297,0.00002118546,0.00001101392,0.00001364074,0.000008634077,0.00001590071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008383254,0.0000619323,0.0006369015,0.0001131562,0.00001642828,0.0006051193,0.00009254025,0.00006993424,0.9849564,0.001980644,0.0004143583,0.01021419],"study_design_scores_gemma":[0.0001298149,0.001205113,0.02195195,0.00002280372,0.00005631363,0.009422592,0.0001184666,0.001324146,0.9528669,0.0009443515,0.01193787,0.0000197575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665065,0.009696667,0.01204327,0.001164918,0.0001937131,0.00008776705,0.0002880841,0.00008915854,0.009929835],"genre_scores_gemma":[0.9889626,0.003054439,0.003483205,0.0002869794,0.00008028507,0.0000434153,0.0007937307,0.00001657157,0.003278767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663306,"threshold_uncertainty_score":0.005564272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04774100988432984,"score_gpt":0.2879597051465322,"score_spread":0.2402186952622024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}