{"id":"W2049408889","doi":"10.1021/bi027076n","title":"Functional and Structural Consequences of Cysteine Substitutions in the NH<sub>2</sub>Proximal Region of the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"ABCC1; Chemistry; Organic anion-transporting polypeptide; Cysteine; ATP-binding cassette transporter; Mutant; Biochemistry; Efflux; Transport protein; Wild type; Glutathione; Trypsin; Transmembrane protein; Molecular biology; Biology; Transporter; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283778,0.0003017627,0.000172411,0.0000963917,0.000136892,0.000171263,0.0002200379,0.0003609776,0.0007476773],"category_scores_gemma":[0.0001739869,0.0001217801,0.0002530516,0.00009928575,0.0003268992,0.0001211557,0.0001413228,0.0002942953,0.0002815269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248735,"about_ca_system_score_gemma":0.0001312866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008982611,"about_ca_topic_score_gemma":0.0007111683,"domain_scores_codex":[0.9998765,0.00004185376,0.00001724611,0.00001964391,0.00002428606,0.00002040249],"domain_scores_gemma":[0.9998153,0.00004023431,0.00008602694,0.00001278702,0.00001298412,0.00003264414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006334243,0.00008443261,0.0009513815,0.00003886344,0.00002031255,0.0004396004,0.0000304574,0.0003508377,0.9961678,0.0001484526,0.00005204546,0.001082319],"study_design_scores_gemma":[0.00008699188,0.0009912724,0.01882,0.00001008979,0.00008106022,0.002600617,0.00009537657,0.002930521,0.9723732,0.0001052039,0.001886187,0.00001955145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994056,0.0001180996,0.0002547077,0.00001776777,0.000006004014,0.000004086042,0.00006177498,0.000008109652,0.0001238466],"genre_scores_gemma":[0.9991071,0.0001027146,0.0004221505,0.00002417225,0.000003996206,0.000004780798,0.0001285029,0.000009624113,0.0001969728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008982611,"threshold_uncertainty_score":0.002501249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449727434809622,"score_gpt":0.2255681856286916,"score_spread":0.2110709112805954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}