{"id":"W2049416454","doi":"10.2174/092986706775197908","title":"Natural and Synthetic Biologically Active Dimeric Molecules: Anticancer Agents, Anti-HIV Agents, Steroid Derivatives and Opioid Antagonists","year":2005,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biological activity; Steroid; Chemistry; Human immunodeficiency virus (HIV); Pharmacology; Stereochemistry; Combinatorial chemistry; Biology; Biochemistry; In vitro; Virology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899458,0.0004880427,0.0005385523,0.0008328065,0.0002009883,0.0004512428,0.0004543928,0.0005044396,0.003675466],"category_scores_gemma":[0.0001243961,0.0001787748,0.0001438751,0.0008526256,0.0002886246,0.0007529541,0.0002436497,0.0006860116,0.003730887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004098926,"about_ca_system_score_gemma":0.00040347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003269319,"about_ca_topic_score_gemma":0.0007335359,"domain_scores_codex":[0.999938,0.000008720835,0.000005686538,0.00001328221,0.00002569897,0.000008486576],"domain_scores_gemma":[0.9999542,0.00001221934,0.00001025053,0.000002760527,0.00001259617,0.000007929089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001153947,0.0002218812,0.000148308,0.009228517,0.00003156894,0.0003465843,0.000101816,0.0006975363,0.06472685,0.01019994,0.01324524,0.9009364],"study_design_scores_gemma":[0.00002485859,0.0002410842,0.000534884,0.0003932886,0.0000281797,0.001596917,0.00005635899,0.0001807924,0.01627598,0.001903786,0.9787476,0.00001629688],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002391938,0.9854823,0.002018911,0.0002628048,0.0002565715,0.00002701352,0.00004654458,0.00004047513,0.009473292],"genre_scores_gemma":[0.01325278,0.9730209,0.002724719,0.0003269358,0.0002193901,0.00003319059,0.00009743802,0.000007304827,0.01031732],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003675466,"threshold_uncertainty_score":0.01229566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05367470736058108,"score_gpt":0.339689319133093,"score_spread":0.2860146117725119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}