{"id":"W2049422105","doi":"10.1172/jci64180","title":"Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; BC Cancer Agency; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Human Genome Research Institute; Ontario Ministry of Research and Innovation; Terry Fox Foundation; Stem Cell Network; Ontario Ministry of Health and Long-Term Care; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; International Myeloma Foundation","keywords":"Myeloid leukemia; Lysosome; Biology; Progenitor cell; Leukemia; Cancer research; Cell biology; Stem cell; Haematopoiesis; Cathepsin; Vacuole; LAMP1; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869324,0.0003039519,0.0004401917,0.000273194,0.0001656423,0.0005783513,0.000213348,0.0002992889,0.001202842],"category_scores_gemma":[0.0002135145,0.0001316551,0.0001897046,0.0001931207,0.0002210255,0.0002172054,0.0003026962,0.0004511932,0.0003671684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000349714,"about_ca_system_score_gemma":0.0002483399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000452085,"about_ca_topic_score_gemma":0.001031843,"domain_scores_codex":[0.9997826,0.00004507017,0.0000182552,0.00004775131,0.00006914943,0.00003718709],"domain_scores_gemma":[0.9999042,0.00002590502,0.00002231762,0.00001612555,0.0000121424,0.0000193567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001273087,0.00004031817,0.0005898787,0.0000497268,0.000006342742,0.00008536888,0.0000156641,0.0001096815,0.9958293,0.0002172852,0.00008481884,0.002844487],"study_design_scores_gemma":[0.00002417575,0.0004044774,0.004135155,0.000008597764,0.00001610355,0.0006486801,0.00003114696,0.0006245386,0.9892935,0.0001263123,0.004683799,0.000003543116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985997,0.004840519,0.004809479,0.000177557,0.00002016495,0.00007487673,0.0004632862,0.0001163181,0.003500795],"genre_scores_gemma":[0.9924774,0.002100086,0.002364675,0.000097279,0.000008416599,0.00003044637,0.0005979361,0.00002461764,0.002299114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202842,"threshold_uncertainty_score":0.00402391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05401678840932425,"score_gpt":0.3679316941701927,"score_spread":0.3139149057608684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}