{"id":"W2049442243","doi":"10.1089/ten.tec.2011.0147","title":"Membrane Culture of Bone Marrow Stromal Cells Yields Better Tissue Than Pellet Culture for Engineering Cartilage-Bone Substitute Biphasic Constructs in a Two-Step Process","year":2011,"lang":"en","type":"article","venue":"Tissue Engineering Part C Methods","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Mount Sinai Hospital; University of Guelph; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cartilage; Tissue engineering; Stromal cell; Biomedical engineering; Extracellular matrix; Hyaline cartilage; Scaffold; Cell culture; Mesenchymal stem cell; Bone marrow; Cell biology; Chondrogenesis; Tissue culture; Membrane; In vitro; Chemistry; Materials science; Osteoarthritis; Anatomy; Pathology; Biology; Medicine; Articular cartilage; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005444192,0.000541852,0.001102795,0.0002981779,0.00004491903,0.00002000554,0.0001507096,0.000305547,0.0001591348],"category_scores_gemma":[0.0001560483,0.0005024441,0.0001596821,0.000430218,0.00005414268,0.0001759507,0.0000446066,0.0004060189,0.00001140494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005811863,"about_ca_system_score_gemma":0.00005658697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002390362,"about_ca_topic_score_gemma":0.00001496173,"domain_scores_codex":[0.9977375,0.00005970615,0.0006804725,0.000541941,0.0002864756,0.0006938696],"domain_scores_gemma":[0.9988716,0.00009795518,0.0001607888,0.0004505528,0.0001318945,0.0002872503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001772542,0.0001147498,0.0001523,0.001241909,0.00007629107,0.0002867507,0.003466517,0.0004490619,0.9870902,0.0004257951,0.00009569453,0.006423506],"study_design_scores_gemma":[0.004060325,0.001086209,0.00004404749,0.0007862669,0.0002961965,0.0002525892,0.0001866276,0.000941131,0.9794028,0.00002165705,0.01246007,0.0004620839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.89507,0.004246138,0.09476282,0.00007115758,0.00177366,0.0027663,0.0001430217,0.0003921113,0.0007748154],"genre_scores_gemma":[0.5089106,0.00004830542,0.4889448,0.00002410975,0.0003230858,0.0002422615,0.0000869571,0.0001022949,0.001317579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.394182,"threshold_uncertainty_score":0.9997427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480625705981391,"score_gpt":0.3098918533213335,"score_spread":0.2850855962615195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}