{"id":"W2049519756","doi":"10.1002/anie.200502666","title":"Photochemical Regulation of DNA‐Binding Specificity of MyoD","year":2005,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"MyoD; Linker; Isomerization; DNA; Azobenzene; Helix (gastropod); Chemistry; Conformational isomerism; Biophysics; Sequence (biology); Photoisomerization; Computational biology; Computer science; Biochemistry; Biology; Gene; Molecule; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207643,0.0001675704,0.0001287119,0.00008837309,0.0001338169,0.0002553103,0.0002167785,0.000223449,0.001251572],"category_scores_gemma":[0.0002289156,0.0001226735,0.0001228159,0.00007530247,0.0002708361,0.0001429712,0.0002307466,0.0003805047,0.0002611607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005184771,"about_ca_system_score_gemma":0.0001273272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00049593,"about_ca_topic_score_gemma":0.001000357,"domain_scores_codex":[0.9998946,0.00001426167,0.000006194347,0.00003172823,0.00002809781,0.00002506685],"domain_scores_gemma":[0.9998935,0.00004271239,0.00002631002,0.00001062901,0.00001088213,0.00001586426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001842619,0.000003724701,0.00003696249,0.000007390814,8.708686e-7,0.000004055722,0.000004621332,0.00002046498,0.9995412,0.00004421626,0.00001003357,0.0003081106],"study_design_scores_gemma":[0.000003763434,0.00001550955,0.0008278029,0.000001051472,0.000001599402,0.0000168283,0.000004122211,0.0003466344,0.9983292,0.00001698024,0.0004343128,0.000002119795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993275,0.0008954537,0.003552161,0.000148926,0.00003372535,0.00001198449,0.0001316469,0.00007682126,0.001874246],"genre_scores_gemma":[0.9975521,0.0003150403,0.0009149621,0.00005009686,0.000004650092,0.00001037273,0.00007594434,0.00001788945,0.001058911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251572,"threshold_uncertainty_score":0.004186928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009668427652655232,"score_gpt":0.2819756325606184,"score_spread":0.2723072049079632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}