{"id":"W2049519756","doi":"10.1002/anie.200502666","title":"Photochemical Regulation of DNA‐Binding Specificity of MyoD","year":2005,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"MyoD; Linker; Isomerization; DNA; Azobenzene; Helix (gastropod); Chemistry; Conformational isomerism; Biophysics; Sequence (biology); Photoisomerization; Computational biology; Computer science; Biochemistry; Biology; Gene; Molecule; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007783874,0.00007429803,0.00008334283,0.00004437466,0.00001169375,0.000004361891,0.0001040128,0.0000848752,0.0001533756],"category_scores_gemma":[0.00005928353,0.00008118322,0.00007105057,0.00004330349,0.00003770275,0.000007532722,0.00003600921,0.00004182115,0.000002841728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002306574,"about_ca_system_score_gemma":0.00001411637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000363725,"about_ca_topic_score_gemma":0.000003347466,"domain_scores_codex":[0.9993933,0.000004419659,0.0002160376,0.0001411563,0.000168509,0.00007652561],"domain_scores_gemma":[0.9996153,0.000009783611,0.00009945386,0.0001142615,0.0001347432,0.00002645466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004142299,0.00004689304,0.0004047444,0.00001363825,0.00002927543,1.154871e-7,0.00003119075,0.0002207934,0.9956651,0.00006242479,0.003024093,0.0004603055],"study_design_scores_gemma":[0.0002951108,0.00003118074,0.001918542,0.00002602239,0.000008518484,0.000005280666,0.00002438797,0.0001625354,0.9881753,0.00005660837,0.009221933,0.00007454338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739984,0.00007453263,0.02064223,0.0001532088,0.0003049823,0.00007720474,0.00006724797,0.000008512196,0.004673708],"genre_scores_gemma":[0.9965715,0.00005299629,0.001432332,0.00001980661,0.001080851,0.000007352467,0.0005698834,0.000008818434,0.0002565004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02257308,"threshold_uncertainty_score":0.3310556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009668427652655232,"score_gpt":0.2819756325606184,"score_spread":0.2723072049079632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}