{"id":"W2049606715","doi":"10.1172/jci59334","title":"Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; University of Toronto; Cancer Research UK; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Temozolomide; Methyltransferase; Cancer research; O-6-methylguanine-DNA methyltransferase; DNA repair; DNA methylation; Methylation; Base excision repair; DNA damage; DNA methyltransferase; DNA glycosylase; Biology; Glioma; Chemotherapy; Gene silencing; Medicine; DNA; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743757,0.000305969,0.0003993868,0.0002678501,0.0001071735,0.0002272597,0.0001403469,0.0001765163,0.0008064947],"category_scores_gemma":[0.00007119075,0.0001440265,0.000221374,0.0002258843,0.0001275132,0.0001511361,0.0001393096,0.0007355465,0.0001647602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003470795,"about_ca_system_score_gemma":0.0002550176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002687569,"about_ca_topic_score_gemma":0.003687788,"domain_scores_codex":[0.9998792,0.00001750163,0.00001100838,0.00002187671,0.00003939814,0.00003098414],"domain_scores_gemma":[0.9999186,0.000007541243,0.00001965633,0.00001003014,0.00001087491,0.000033278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003885803,0.0001702517,0.001407897,0.00003698894,0.00002822786,0.00005722979,0.00003140615,0.0001246413,0.9953376,0.0000719361,0.0001993468,0.00214592],"study_design_scores_gemma":[0.00007306103,0.005040507,0.06380989,0.00001458236,0.0001056326,0.0007749044,0.0001202863,0.006479724,0.9194723,0.00009714989,0.003997511,0.00001436777],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976399,0.0008230634,0.0006415317,0.00006474984,0.00002630842,0.00001518418,0.0003959091,0.00005615278,0.0003372575],"genre_scores_gemma":[0.9965413,0.0005871678,0.0005575222,0.00002541324,0.000005531666,0.00002633243,0.00105153,0.000009197379,0.001195764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002687569,"threshold_uncertainty_score":0.005343854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07493974418375068,"score_gpt":0.3211513829511787,"score_spread":0.246211638767428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}