{"id":"W2049658474","doi":"10.1021/bi0106787","title":"Vgb from<i>Staphylococcus aureus</i>Inactivates Streptogramin B Antibiotics by an Elimination Mechanism Not Hydrolysis","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Streptomyces coelicolor; Antibiotics; Chemistry; Depsipeptide; Stereochemistry; Enzyme; Biochemistry; Bacteria; Staphylococcus aureus; Microbiology; Streptomyces; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009707863,0.0002132669,0.0001706594,0.000008541338,0.0001741256,0.000104373,0.0003294972,0.0002592423,0.0002972602],"category_scores_gemma":[0.00002616188,0.0001042919,0.00009378599,0.0002428222,0.00005189225,0.00009577008,0.00007311785,0.000141063,0.00001635715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004248254,"about_ca_system_score_gemma":0.000007034568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002125286,"about_ca_topic_score_gemma":0.00002613663,"domain_scores_codex":[0.9987493,0.00002639576,0.0002122805,0.0004656197,0.0002266823,0.0003197425],"domain_scores_gemma":[0.9994791,0.00004544282,0.0001178611,0.0001395874,0.0000532299,0.0001647649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002433722,0.0002655609,0.0008181056,0.000003587646,0.00002317596,0.000004511139,0.00001465123,6.672655e-7,0.9842502,0.00004613234,0.000475958,0.01407314],"study_design_scores_gemma":[0.0001397273,0.0001574169,0.00287104,0.00001393343,0.0000265764,0.000001434071,0.0002475238,0.0006119958,0.9931996,0.0005712383,0.001884769,0.0002747474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976317,0.0001106417,0.00003900602,0.0008815536,0.00006955999,0.0001019628,0.0003996333,0.0001082311,0.0006576972],"genre_scores_gemma":[0.9973595,0.0001229118,0.0001823986,0.0002233063,0.0002532428,0.000001829502,0.001539788,0.00000249087,0.0003144903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01379839,"threshold_uncertainty_score":0.42529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009783501784930962,"score_gpt":0.2070644241749619,"score_spread":0.1972809223900309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}