{"id":"W2049675392","doi":"10.1016/j.tiv.2007.01.003","title":"Induction of cytochrome P450 1a1 by the food flavoring agent, maltol","year":2007,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Maltol; Aryl hydrocarbon receptor; Chemistry; CYP1B1; Cytochrome P450; Biochemistry; Toxicity; Transfection; CYP1A2; CYP2B6; Gene expression; Cytochrome c; Pharmacology; Molecular biology; Enzyme; Gene; Apoptosis; Biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332359,0.0004547431,0.0002097503,0.0002599373,0.0002172992,0.000287693,0.0001385819,0.0002749214,0.002166682],"category_scores_gemma":[0.000258322,0.0001845866,0.0002818537,0.0002055783,0.0001994433,0.0001813992,0.0001850946,0.0004499937,0.0003279271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004288065,"about_ca_system_score_gemma":0.0002829951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002859494,"about_ca_topic_score_gemma":0.004101493,"domain_scores_codex":[0.999849,0.00004483206,0.00001057758,0.00002304568,0.00003017625,0.00004237795],"domain_scores_gemma":[0.9998084,0.00006705254,0.0000321721,0.00002310389,0.00003990974,0.00002934918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004959045,0.00006380559,0.0004360387,0.00003628796,0.000007782458,0.00007369868,0.00002661972,0.00006549116,0.9973164,0.00007701262,0.00007851187,0.001322458],"study_design_scores_gemma":[0.000009677454,0.0003452467,0.001732895,0.000003043375,0.00001002111,0.00005713672,0.00002141506,0.0002407552,0.9969471,0.00002279038,0.0006078688,0.000002192136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957573,0.001133713,0.001240723,0.0001457363,0.0000429071,0.0000194784,0.000308085,0.00004188168,0.001310265],"genre_scores_gemma":[0.9950092,0.0007583749,0.000554571,0.00004248004,0.00001224679,0.0000132862,0.0007164891,0.00001161474,0.002881768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002859494,"threshold_uncertainty_score":0.007248282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589432850201261,"score_gpt":0.2564945847987787,"score_spread":0.2406002562967661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}