{"id":"W2049687409","doi":"10.3390/cancers5030739","title":"Synthetic Genetic Targeting of Genome Instability in Cancer","year":2013,"lang":"en","type":"article","venue":"Cancers","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Synthetic lethality; Cancer; Epigenetics; Computational biology; Lethality; Personalized medicine; Precision medicine; Drug discovery; Cancer cell; Biology; Bioinformatics; Gene; Genetics; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009559547,0.00009510518,0.0001273162,0.00003045562,0.00001533751,0.000005053549,0.0001475333,0.00007794621,0.0002568882],"category_scores_gemma":[0.00005288398,0.00009544684,0.00004903551,0.00008571218,0.00006953216,0.000002817751,0.00006184418,0.00005185351,0.000007698367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070743,"about_ca_system_score_gemma":0.0002574958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001304669,"about_ca_topic_score_gemma":0.000212077,"domain_scores_codex":[0.9992048,0.00003747782,0.0002023247,0.0002693335,0.0000780745,0.0002079789],"domain_scores_gemma":[0.999549,0.000005580296,0.00006817243,0.0002656055,0.00005960338,0.00005200434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001037014,0.000008996327,0.007157178,0.00003814329,0.00001276167,5.832488e-7,0.00007510064,0.004110813,0.9863514,0.00000934199,0.00009431072,0.002131014],"study_design_scores_gemma":[0.0005754174,0.0002009059,0.04411849,0.00004336143,0.00001499745,0.000002260093,0.0003433611,0.001423769,0.9468253,0.0003211056,0.005783388,0.0003476423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969231,0.001826976,0.0001933076,0.00003196215,0.0001295957,0.0002478015,0.00001084849,0.000007097496,0.000629344],"genre_scores_gemma":[0.998336,0.0002330632,0.001015608,0.00008900344,0.00005494579,0.0001389491,0.000007376448,0.00001618296,0.0001088673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03952609,"threshold_uncertainty_score":0.3892209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008721596789262105,"score_gpt":0.2366668040698165,"score_spread":0.2279452072805544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}