{"id":"W2049687409","doi":"10.3390/cancers5030739","title":"Synthetic Genetic Targeting of Genome Instability in Cancer","year":2013,"lang":"en","type":"article","venue":"Cancers","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Synthetic lethality; Cancer; Epigenetics; Computational biology; Lethality; Personalized medicine; Precision medicine; Drug discovery; Cancer cell; Biology; Bioinformatics; Gene; Genetics; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005753439,0.0004070856,0.0002829849,0.0005870831,0.0003199244,0.0004458901,0.0003698986,0.0005452411,0.001039492],"category_scores_gemma":[0.0003804133,0.0002202718,0.0003154904,0.0002701707,0.0007555546,0.0004152135,0.0006587022,0.0007939114,0.0002598525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004293775,"about_ca_system_score_gemma":0.0003241051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002469175,"about_ca_topic_score_gemma":0.0003881399,"domain_scores_codex":[0.9996349,0.0001241572,0.00002762048,0.00005271815,0.0001237401,0.00003685283],"domain_scores_gemma":[0.9997769,0.00007888952,0.00006842389,0.00003777638,0.00001429238,0.00002368928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001105403,0.00006658931,0.0002513888,0.0002533431,0.00002067292,0.0001959021,0.00004619427,0.001750718,0.9721454,0.01172897,0.0003104383,0.01311976],"study_design_scores_gemma":[0.00003285469,0.000925057,0.000844427,0.00002966029,0.00004020031,0.001287639,0.0000308812,0.002694637,0.9686157,0.002865039,0.02260791,0.00002600631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5999463,0.03878459,0.328608,0.002480082,0.0005629648,0.0006894159,0.0009255684,0.001743033,0.02625993],"genre_scores_gemma":[0.9366642,0.01677728,0.0413291,0.0003204404,0.00006392905,0.0002348279,0.0003446922,0.0001020606,0.004163444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039492,"threshold_uncertainty_score":0.003477514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008721596789262105,"score_gpt":0.2366668040698165,"score_spread":0.2279452072805544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}