{"id":"W2049723387","doi":"10.1021/bi0487692","title":"Identification of Key Residues in the A-Raf Kinase Important for Phosphoinositide Lipid Binding Specificity","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Kinase; Phosphatidylinositol; Biochemistry; c-Raf; Cell biology; C2 domain; Phosphatidic acid; Signal transduction; Protein kinase domain; Mutant; Chemistry; Biology; Protein kinase A; Mitogen-activated protein kinase kinase; Membrane; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000966661,0.0002897238,0.0001707293,0.0001819302,0.0001648397,0.0002259297,0.0003055437,0.0003615005,0.00125],"category_scores_gemma":[0.0001977793,0.0001226611,0.0002312181,0.0001195105,0.0001920148,0.0002127818,0.000155333,0.000443667,0.0008027541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321503,"about_ca_system_score_gemma":0.0001842348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006013975,"about_ca_topic_score_gemma":0.0006608649,"domain_scores_codex":[0.9999325,0.00001008763,0.00000612169,0.00001649493,0.00001783629,0.00001692299],"domain_scores_gemma":[0.9998875,0.00002023614,0.00002777985,0.00001033476,0.00001827175,0.00003588848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001656205,0.00003639007,0.0003645424,0.00002964494,0.000003650337,0.0001229941,0.000008856561,0.0001086443,0.9971924,0.0001914553,0.00004458937,0.001731172],"study_design_scores_gemma":[0.00005392366,0.0003813274,0.02498415,0.00001800541,0.00003307725,0.001671332,0.0000410574,0.002720832,0.9633657,0.0004006523,0.006313337,0.00001647046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892958,0.002862312,0.00494862,0.0001521815,0.00005970277,0.00007624384,0.0005531858,0.00006321307,0.001988717],"genre_scores_gemma":[0.9910546,0.001306909,0.004876808,0.00008189392,0.00002246945,0.00002945323,0.0009391687,0.00001313893,0.001675637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125,"threshold_uncertainty_score":0.004181683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182483567150565,"score_gpt":0.2472471304545427,"score_spread":0.2354222947830371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}