{"id":"W2049778128","doi":"10.1038/onc.2014.425","title":"SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma","year":2014,"lang":"en","type":"article","venue":"Oncogene","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Biology; Hepatocellular carcinoma; Gene knockdown; Cancer research; Carcinogenesis; Transforming growth factor beta; Oncology; Immunology; Cancer; Transforming growth factor; Cell culture; Endocrinology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603689,0.000309799,0.0001928863,0.000603219,0.0002240647,0.0002535547,0.0001840415,0.0001785685,0.002351013],"category_scores_gemma":[0.0001058316,0.0001661173,0.000290972,0.0002448278,0.0002593258,0.0001855951,0.0002235898,0.0003437159,0.0004144808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704124,"about_ca_system_score_gemma":0.0003067699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008069597,"about_ca_topic_score_gemma":0.0007805192,"domain_scores_codex":[0.9999359,0.00001653231,0.000004849104,0.00000618714,0.00001465359,0.00002190547],"domain_scores_gemma":[0.9999274,0.000008500985,0.00001520969,0.000009522977,0.0000102757,0.0000290669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009294793,0.00006965185,0.002586729,0.00009291701,0.00002563316,0.0003681374,0.00001868783,0.0001139274,0.9913847,0.0006065696,0.0001535961,0.003649884],"study_design_scores_gemma":[0.00007626002,0.0004847292,0.0488161,0.000008114018,0.0001176225,0.001532225,0.0001480777,0.001318472,0.9406294,0.0004632726,0.006392903,0.00001286516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888964,0.005125533,0.001479323,0.0003220152,0.00005273841,0.00001358526,0.0002427284,0.0001116093,0.003756148],"genre_scores_gemma":[0.9942023,0.001489985,0.0003792273,0.00003657057,0.00002153811,0.00001085122,0.0002140878,0.000008170844,0.003637197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002351013,"threshold_uncertainty_score":0.007864952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006768751095935666,"score_gpt":0.2144898170804993,"score_spread":0.2077210659845636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}