{"id":"W2049801826","doi":"10.1073/pnas.0908083106","title":"GluN2B subunit-containing NMDA receptor antagonists prevent Aβ-mediated synaptic plasticity disruption in vivo","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland; Health Research Board","keywords":"NMDA receptor; Synaptic plasticity; Memantine; Neuroscience; Metaplasticity; Biology; Chemistry; Pharmacology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001277538,0.0001345653,0.0001961531,0.0003753021,0.0003348069,0.00004590941,0.001237435,0.00008104468,0.00004284596],"category_scores_gemma":[0.003662392,0.000096984,0.00006317985,0.002031345,0.001322432,0.0007762382,0.0001612038,0.0004094675,0.000005602082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006949202,"about_ca_system_score_gemma":0.00007936502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003254446,"about_ca_topic_score_gemma":1.038508e-7,"domain_scores_codex":[0.9971195,0.00005248214,0.000430946,0.0005040108,0.001512746,0.0003803248],"domain_scores_gemma":[0.9988004,0.0006185523,0.0003727251,0.000010646,0.0001218358,0.00007583162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000818554,0.0001610347,0.002785495,0.0000176985,0.0000011657,9.314282e-8,0.0001187952,0.00007299432,0.9921651,0.004303765,0.0001084538,0.0001835753],"study_design_scores_gemma":[0.0002763355,0.0002895409,0.02113922,0.00006403631,0.000003113407,0.00001123835,0.00005017356,0.003386773,0.9713423,0.003267019,0.00007595333,0.00009435508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952111,0.00001007336,5.586835e-7,0.003342074,0.0000514361,0.0003291502,0.00001939464,0.00002177955,0.001014414],"genre_scores_gemma":[0.9985989,0.00009067408,0.0000448631,0.001091883,0.00004471165,0.0000124351,3.099903e-8,0.000004254788,0.0001122482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02082283,"threshold_uncertainty_score":0.4872555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06814644902127114,"score_gpt":0.3640240414245518,"score_spread":0.2958775924032807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}