{"id":"W2049832374","doi":"10.2174/1568011043482197","title":"Reversing Agents for ATP-Binding Cassette (ABC) Transporters: Application in Modulating Multidrug Resistance (MDR)","year":2004,"lang":"en","type":"review","venue":"Current Medicinal Chemistry - Anti-Cancer Agents","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Northern British Columbia","funders":"","keywords":"ATP-binding cassette transporter; Multiple drug resistance; Abcg2; Reversing; Transporter; P-glycoprotein; Phenotype; Biology; Membrane protein; Multidrug Resistance-Associated Proteins; Drug resistance; Pharmacology; Gene; Biochemistry; Genetics; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002274195,0.0005875959,0.0008082538,0.00146597,0.0002508639,0.000385114,0.0005794839,0.0007435108,0.004259855],"category_scores_gemma":[0.0001791091,0.000173664,0.0003190676,0.001230771,0.0002875178,0.0007889411,0.0002493286,0.0009064215,0.003134121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916936,"about_ca_system_score_gemma":0.0002977631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004405279,"about_ca_topic_score_gemma":0.0009951375,"domain_scores_codex":[0.9999063,0.00001446251,0.000009873803,0.00001906106,0.00004134486,0.000008893549],"domain_scores_gemma":[0.9999263,0.00002712034,0.0000138705,0.000004395028,0.00001924997,0.000009113974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007884055,0.0002224066,0.0001912342,0.00720663,0.00003945926,0.0004505789,0.00007713725,0.000364186,0.0272621,0.002714219,0.006541449,0.9548519],"study_design_scores_gemma":[0.00005276984,0.0006515557,0.001642623,0.0009786373,0.0001162521,0.004951192,0.00007348612,0.0002085458,0.02145904,0.001327561,0.9685112,0.00002719184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001527479,0.993522,0.0007405906,0.0001443503,0.0001584846,0.00001718153,0.00001969765,0.00002555515,0.003844666],"genre_scores_gemma":[0.005872957,0.9892279,0.001315474,0.0001819331,0.0001509679,0.00001732167,0.00004669066,0.000003924863,0.003182892],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004259855,"threshold_uncertainty_score":0.01425064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08804125410547418,"score_gpt":0.3972375094363839,"score_spread":0.3091962553309097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}