{"id":"W2049843327","doi":"10.1016/j.cub.2008.04.073","title":"Evolution of HIV-1 Isolates that Use a Novel Vif-Independent Mechanism to Resist Restriction by Human APOBEC3G","year":2008,"lang":"en","type":"article","venue":"Current Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health; Campbell Foundation; University of Minnesota; Canadian Institutes of Health Research; Mayo Foundation for Medical Education and Research","keywords":"Biology; APOBEC3G; Mechanism (biology); Resist; Human immunodeficiency virus (HIV); Genetics; Virology; Evolutionary biology; DNA; Cytidine deaminase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001238142,0.0002027204,0.000319684,0.0002557602,0.0003185349,0.000006325667,0.0002168591,0.0002608884,0.0001968509],"category_scores_gemma":[0.00008258459,0.0001703636,0.000106421,0.0001722014,0.0002110236,0.0000793552,0.0001409302,0.0002700806,0.00088501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114543,"about_ca_system_score_gemma":0.00007823757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005726731,"about_ca_topic_score_gemma":0.0000677494,"domain_scores_codex":[0.9985195,0.0002075783,0.0003020255,0.0004380107,0.0000469715,0.000485891],"domain_scores_gemma":[0.9992757,0.0001008946,0.0001317867,0.0003217231,0.0001017252,0.0000681647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001963269,0.0007266529,0.04246512,0.00001302304,0.0001318694,0.000002253836,0.00013666,0.000001430416,0.9309376,0.006123298,0.01853071,0.0007350492],"study_design_scores_gemma":[0.009731163,0.004646949,0.2532179,0.0001398461,0.0001875096,0.0002175827,0.0002811765,0.00001242629,0.4385646,0.002185947,0.2898236,0.0009912479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986408,0.004023486,0.006810382,0.0001912154,0.0008164551,0.0005037618,0.001060266,0.00007315646,0.000113265],"genre_scores_gemma":[0.9967527,0.0004609257,0.00006671334,0.00001424926,0.00003253071,0.00007229441,0.001550457,0.00001317186,0.001036936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.492373,"threshold_uncertainty_score":0.9998929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05737042878814015,"score_gpt":0.2994190636079005,"score_spread":0.2420486348197604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}