{"id":"W2049852944","doi":"10.1515/hc.2008.14.5.385","title":"2-(3-ARYLACRYLOYL)-3-METHYLQUINOXALINE 1,4-DIOXIDES AS POTENTIAL HYPOXIC SELECTIVE CYTOTOXINS","year":2008,"lang":"en","type":"article","venue":"Heterocyclic Communications","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Cytotoxicity; Combinatorial chemistry; Pharmacology; Stereochemistry; Biochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001216388,0.0002713917,0.0003620678,0.00007111236,0.0008294472,0.00003418794,0.001231627,0.0002303715,0.001184467],"category_scores_gemma":[0.0002977345,0.0002337219,0.0002730832,0.0002231213,0.000465084,0.0001562093,0.0005719509,0.0005065632,0.0003566777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247817,"about_ca_system_score_gemma":0.00004071768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002879494,"about_ca_topic_score_gemma":0.00008126078,"domain_scores_codex":[0.9983827,0.0001663395,0.0004103424,0.0004045152,0.0002372835,0.0003988378],"domain_scores_gemma":[0.9970366,0.0005622052,0.0001847877,0.001947151,0.0001003114,0.0001689493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005508211,0.0008585442,0.003241633,0.00001271118,0.0001128353,0.00001336421,0.0001874256,0.000007498267,0.9860395,0.0002158703,0.0006249888,0.008630595],"study_design_scores_gemma":[0.001100565,0.0001507516,0.02533338,0.00006573395,0.0001088788,0.0006963043,0.0003303559,0.000895441,0.9142693,0.002921956,0.05314099,0.0009863774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589389,0.001038032,0.0002066533,0.001084442,0.00003899611,0.0001217097,0.00005223592,0.0003184618,0.03820059],"genre_scores_gemma":[0.9952838,0.001102409,0.001832516,0.0002522054,0.0001382332,0.0001301873,0.00008406413,0.0000289121,0.001147671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07177018,"threshold_uncertainty_score":0.9997286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04316462557830602,"score_gpt":0.2756894825239549,"score_spread":0.2325248569456489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}