{"id":"W2049877184","doi":"10.1073/pnas.1312739110","title":"Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust; GlaxoSmithKline; Pfizer","keywords":"Kinase; Peptide; Proteolysis; Biophysics; Substrate (aquarium); Chemistry; SH3 domain; Biochemistry; Cell biology; Biology; Enzyme; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003729378,0.0002257891,0.0002947339,0.0001164756,0.0001016822,0.0003349999,0.0002324912,0.00032066,0.0003712415],"category_scores_gemma":[0.0008399945,0.000133406,0.0001579632,0.0001095147,0.0003134174,0.0003034758,0.0002435285,0.0005180718,0.0002007127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002909431,"about_ca_system_score_gemma":0.0001302167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000148248,"about_ca_topic_score_gemma":0.0001962296,"domain_scores_codex":[0.9997117,0.00005105939,0.000009653486,0.00006535617,0.0001210354,0.00004118713],"domain_scores_gemma":[0.99966,0.0001642014,0.00007337658,0.00002543563,0.00003220597,0.00004475567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000475409,0.00000953695,0.0004810623,0.0000257577,0.000003595397,0.00004899064,0.00001230656,0.0001699416,0.9978492,0.0001853766,0.00002657197,0.001140066],"study_design_scores_gemma":[0.000002715775,0.00007094428,0.002270439,0.000001647905,0.000003427216,0.000254234,0.00001054522,0.00530252,0.9916966,0.00009664934,0.0002846597,0.000005674457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675639,0.0005867701,0.0301115,0.0001180749,0.00002792665,0.00003715531,0.0001479581,0.0001237783,0.001282931],"genre_scores_gemma":[0.990352,0.0002652137,0.00868381,0.00005369138,0.00001154256,0.00002330992,0.00007542567,0.000007342532,0.000527552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003729378,"threshold_uncertainty_score":0.002110958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884617095176463,"score_gpt":0.2855362700754397,"score_spread":0.2666900991236751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}