{"id":"W2049893427","doi":"10.1371/journal.ppat.1003578","title":"Aggressive Chemotherapy and the Selection of Drug Resistant Pathogens","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of General Medical Sciences; Science and Technology Directorate; Fogarty International Center; National Institutes of Health; U.S. Department of Homeland Security","keywords":"Drug resistance; Transmission (telecommunications); Drug; Biology; Intensive care medicine; Disease; Malaria; Pathogen; Resistance (ecology); Medicine; Pharmacology; Immunology; Microbiology; Internal medicine; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003094551,0.0001461587,0.0002586705,0.0001775344,0.0002520497,0.0005025374,0.000171041,0.0003952407,0.0008902861],"category_scores_gemma":[0.0007105623,0.0001197385,0.0001344186,0.0001633201,0.0005144339,0.0003700499,0.0003369877,0.000490573,0.0001157587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005226476,"about_ca_system_score_gemma":0.0002497078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007140365,"about_ca_topic_score_gemma":0.0009942771,"domain_scores_codex":[0.9997312,0.0001235425,0.00001119425,0.00003854306,0.00004618437,0.00004926161],"domain_scores_gemma":[0.99959,0.0001008393,0.0001686448,0.00004579634,0.00002662124,0.00006823042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006890529,0.000222943,0.01591709,0.00007178568,0.00003508224,0.0003125459,0.0001513618,0.003239001,0.9463692,0.004628533,0.0005672125,0.02779622],"study_design_scores_gemma":[0.0003141269,0.006603552,0.2966239,0.0001405574,0.0002208578,0.004808683,0.0008109721,0.03611604,0.5890186,0.01675464,0.04844463,0.0001433484],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932987,0.001854794,0.001846554,0.0006145376,0.00002345624,0.00001559736,0.00004097763,0.00002327552,0.002282143],"genre_scores_gemma":[0.9978987,0.0006796577,0.0006822088,0.0002000875,0.000007876157,0.000007084259,0.00002179065,0.000005425571,0.0004970775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008902861,"threshold_uncertainty_score":0.003792048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004141697971416494,"score_gpt":0.2012293850954675,"score_spread":0.197087687124051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}