{"id":"W2049923610","doi":"10.1016/j.ab.2010.11.022","title":"Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: Cellular distribution in human leukocyte populations and evidence of diurnal modulation","year":2010,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cathepsin; Ex vivo; Molecular biology; Cathepsin H; Whole blood; In vivo; Cathepsin D; Chemistry; Western blot; Cathepsin B; Biochemistry; Biology; In vitro; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003751047,0.00014963,0.0001547547,0.00002935344,0.00008634274,0.0000270891,0.0001377154,0.000238958,0.000004429178],"category_scores_gemma":[0.0002035189,0.0001271274,0.00006510084,0.0001757732,0.0001445759,0.00001785365,0.00007282691,0.0003217868,3.465297e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002903548,"about_ca_system_score_gemma":0.00009914888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001917946,"about_ca_topic_score_gemma":0.00007391198,"domain_scores_codex":[0.9989845,0.00006187324,0.0002290585,0.0003568953,0.0001586346,0.0002090877],"domain_scores_gemma":[0.9994045,0.00002312959,0.0001259832,0.0003252122,0.00005300363,0.0000681512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005639837,0.00023712,0.003962177,0.00005987861,0.00000854211,0.00000155633,0.00000857897,0.00003304683,0.9952822,0.00007532749,0.000025954,0.0002492614],"study_design_scores_gemma":[0.0004425993,0.00008789976,0.002998968,0.00009610316,0.00002750021,0.000003120296,0.000008121463,0.006371468,0.989605,0.0001918371,0.00002300238,0.0001443593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964469,0.0001655902,0.002719825,0.0003673183,0.00001991432,0.0002270327,0.0000295773,0.000005807979,0.00001801463],"genre_scores_gemma":[0.9995747,0.000004574045,0.0001052839,0.00001702713,0.0000622564,0.00002918938,0.000146338,0.00000985143,0.00005078039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006338421,"threshold_uncertainty_score":0.5184103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.018134140555306,"score_gpt":0.2748245221360194,"score_spread":0.2566903815807134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}